Hyun Gi Kim1, Na-Young Shin2,3, Yunjin Bak4, Kyung Ran Kim5, Young-Chul Jung5, Kyunghwa Han6, Seung-Koo Lee6, Soo Mee Lim4. 1. Department of Radiology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea. 2. Department of Radiology, Ewha Womans University School of Medicine, 911-1 Mokdong, Yangcheon-gu, Seoul, 158-710, Korea. nyshin@ewha.ac.kr. 3. Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. nyshin@ewha.ac.kr. 4. Department of Radiology, Ewha Womans University School of Medicine, 911-1 Mokdong, Yangcheon-gu, Seoul, 158-710, Korea. 5. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea. 6. Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVES: To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx). METHODS: Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results. RESULTS: Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test. CONCLUSIONS: We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx. KEY POINTS: • Intrinsic brain activity of gastric cancer patients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region.
OBJECTIVES: To characterize the pattern of altered intrinsic brain activity in gastric cancerpatients after chemotherapy (CTx). METHODS:Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results. RESULTS:Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test. CONCLUSIONS: We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancerpatients who underwent CTx. KEY POINTS: • Intrinsic brain activity of gastric cancerpatients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region.
Entities:
Keywords:
Brain; Cancer chemotherapy agents; Cognitive function; Functional magnetic resonance imaging; Gastric cancer
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