| Literature DB >> 27878518 |
Sneha Yadav1, Virendra Tiwari1, Manjari Singh1, Rajnish K Yadav1, Subhadeep Roy1, Uma Devi2, Swetlana Gautam1, Jitendra Kumar Rawat1, Mohd Nazam Ansari3, Abdulaziz Sa Saeedan3, Anand Prakash4, Shubhini A Saraf1, Gaurav Kaithwas5.
Abstract
The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.Entities:
Keywords: Alpha-linolenic acid; Autism spectrum disorder; Gamma-linolenic acid; Pgp 9.5; Polyunsaturated fatty acids
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Year: 2016 PMID： 27878518 DOI： 10.1007/s13105-016-0532-2
Source DB: PubMed Journal: J Physiol Biochem ISSN： 1138-7548 Impact factor: 4.158