Ilana Levy1, Samuel Attias2,3, Eran Ben-Arye4,5, Lee Goldstein4,6, Ibrahim Matter4,7, Mostafa Somri4,8, Elad Schiff9,2,4. 1. Internal Medicine B Department, Bnai Zion Medical Center, Golomb 47, 3339419, Haifa, Israel. ilana.levy@b-zion.org.il. 2. Complementary Medicine Department, Bnai Zion Medical Center, Haifa, Israel. 3. School of Public Health, University of Haifa, Haifa, Israel. 4. Rappaport Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel. 5. Integrative Oncology Program, Oncology Service, Lin Medical Center, Clalit Health Services, Western Galilee District, Haifa, Israel. 6. Clinical Pharmacology Unit, Haemek Medical Center, Afula, Israel. 7. Surgery Department, Bnai Zion Medical Center, Haifa, Israel. 8. Anesthesiology Department, Bnai Zion Medical Center, Haifa, Israel. 9. Internal Medicine B Department, Bnai Zion Medical Center, Golomb 47, 3339419, Haifa, Israel.
Abstract
BACKGROUND: Patients undergoing surgery often use Dietary and Herbal Supplements (DHS). We explored the risk of DHS-drug interactions in the perioperative setting. METHODS: In this cross-sectional prospective study, participants hospitalized for surgery completed a questionnaire regarding DHS use. We used pharmacological databases to assess DHS-drug interactions. We then applied univariate and multivariate logistic regression analyses to characterize patients at risk for DHS-drug interactions. RESULTS: Of 526 interviewees, 230 (44%) patients reported DHS use, with 16.5% reporting using DHS that could potentially interact with anesthesia. Twenty-four (10%) patients used DHS that could potentially interact with antithrombotic drugs taken perioperatively. The medical files of three patients included reports of intraoperative bleeding. The patient files of only 11% of DHS users documented DHS use. CONCLUSIONS: DHS use poses a significant health risk due to potential interactions. Guidelines should emphasize perioperative management of DHS use.
BACKGROUND:Patients undergoing surgery often use Dietary and Herbal Supplements (DHS). We explored the risk of DHS-drug interactions in the perioperative setting. METHODS: In this cross-sectional prospective study, participants hospitalized for surgery completed a questionnaire regarding DHS use. We used pharmacological databases to assess DHS-drug interactions. We then applied univariate and multivariate logistic regression analyses to characterize patients at risk for DHS-drug interactions. RESULTS: Of 526 interviewees, 230 (44%) patients reported DHS use, with 16.5% reporting using DHS that could potentially interact with anesthesia. Twenty-four (10%) patients used DHS that could potentially interact with antithrombotic drugs taken perioperatively. The medical files of three patients included reports of intraoperative bleeding. The patient files of only 11% of DHS users documented DHS use. CONCLUSIONS:DHS use poses a significant health risk due to potential interactions. Guidelines should emphasize perioperative management of DHS use.
Authors: Dâmaris Silveira; Jose Maria Prieto-Garcia; Fabio Boylan; Omar Estrada; Yris Maria Fonseca-Bazzo; Claudia Masrouah Jamal; Pérola Oliveira Magalhães; Edson Oliveira Pereira; Michal Tomczyk; Michael Heinrich Journal: Front Pharmacol Date: 2020-09-23 Impact factor: 5.810
Authors: Ana Paula Nappi Arruda; Ana Patricia Ayala; Luciane C Lopes; Cristiane C Bergamaschi; Caio Guimarães; Mariana Del Grossi; Leonardo A R Righesso; Arnav Agarwal; Regina El Dib Journal: BMJ Open Date: 2017-07-26 Impact factor: 2.692