Literature DB >> 2787835

omega-Aga-I: a presynaptic calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta.

V P Bindokas1, M E Adams.   

Abstract

Spider venoms are proving to be important sources of specific ion channel toxins. Venom of Agelenopsis aperta, a funnel web spider, contains a class of polypeptide toxins which blocks neuromuscular synapses at nanomolar concentrations. Detailed physiological analyses of block caused by one of these toxins, omega-Aga-I, show that it suppresses transmitter release at insect and frog neuromuscular junctions and blocks calcium spikes in insect neuronal cell bodies. omega-Aga-I may define a binding site on neuronal calcium channels which is common to both vertebrates and invertebrates.

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Year:  1989        PMID： 2787835     DOI： 10.1002/neu.480200402

Source DB:  PubMed          Journal:  J Neurobiol        ISSN： 0022-3034


  8 in total

1.  Inhibition of N- and L-type Ca2+ channels by the spider venom toxin omega-Aga-IIIA.

Authors:  I M Mintz; V J Venema; M E Adams; B P Bean
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

2.  Neurotoxic acylpolyamines from spider venoms.

Authors:  K D McCormick; J Meinwald
Journal:  J Chem Ecol       Date:  1993-10       Impact factor: 2.626

Review 3.  The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals.

Authors:  Adi Lahiani; Ephraim Yavin; Philip Lazarovici
Journal:  Toxins (Basel)       Date:  2017-03-16       Impact factor: 4.546

4.  Venom-Derived Peptides Inhibiting Voltage-Gated Sodium and Calcium Channels in Mammalian Sensory Neurons.

Authors:  Arsalan Yousuf; Mahsa Sadeghi; David J Adams
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

5.  The whole-cell calcium current in acutely dissociated magnocellular cholinergic basal forebrain neurones of the rat.

Authors:  T G Allen; J A Sim; D A Brown
Journal:  J Physiol       Date:  1993-01       Impact factor: 5.182

6.  Multiple transcriptome mining coupled with tissue specific molecular cloning and mass spectrometry provide insights into agatoxin-like peptide conservation in decapod crustaceans.

Authors:  Andrew E Christie; Cindy D Rivera; Catherine M Call; Patsy S Dickinson; Elizabeth A Stemmler; J Joe Hull
Journal:  Gen Comp Endocrinol       Date:  2020-09-09       Impact factor: 2.822

Review 7.  Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy.

Authors:  Saumya Bajaj; Jingyao Han
Journal:  Front Pharmacol       Date:  2019-02-26       Impact factor: 5.810

Review 8.  Venom peptides as a rich source of cav2.2 channel blockers.

Authors:  Silmara R Sousa; Irina Vetter; Richard J Lewis
Journal:  Toxins (Basel)       Date:  2013-02-04       Impact factor: 4.546
  8 in total

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