Literature DB >> 2787821

Analysis of cytotoxic T cell precursor frequencies directed against individual HLA-A and -B alloantigens.

L Zhang1, S G Li, B Vandekerckhove, A Termijtelen, J J Van Rood, F H Claas.   

Abstract

We describe here a limiting dilution analysis to determine cytotoxic T lymphocyte precursor (CTLp) frequencies against individual HLA-A or -B antigens. This assay is reproducible and showed that the CTLp frequency of an individual remains stable with time. Significant variations in CTLp frequency against the same alloantigen were found in different individuals and even in monozygotic twins, showing that these differences were not (completely) genetically determined. Within an individual, a wide range of CTLp frequencies can be found against different allo-antigens. Serologically cross-reactivity seems not to interfere in this assay. This LDA is a practicable tool for a systematic analysis of CTLp response against selected individual HLA-A or -B antigens and can be used for the selection of HLA mismatched donors for transplantation patients.

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Year:  1989        PMID： 2787821     DOI： 10.1016/0022-1759(89)90417-1

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  5 in total

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4.  Association between CTL Precursor Frequency to HLA-C Mismatches and HLA-C Antigen Cell Surface Expression.

Authors:  Moshe Israeli; Dave L Roelen; Mary Carrington; Effie Wang Petersdorf; Frans H J Claas; Geert W Haasnoot; Machteld Oudshoorn
Journal:  Front Immunol       Date:  2014-10-27       Impact factor: 7.561

5.  An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease.

Authors:  S R Burrows; R Khanna; J M Burrows; D J Moss
Journal:  J Exp Med       Date:  1994-04-01       Impact factor: 14.307
  5 in total

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