Literature DB >> 278772

Three chromosomes' (7;9;22) rearrangement and the origin of the Philadelphia chromosome.

D Francesconi, F Pasquali.   

Abstract

A woman with chronic myelocytic leukemia had the Philadelphia chromosome and a complex four-break--three-chromosome rearrangement. The q32 leads to q34 portion of chromosome 9 is translocated to band q22 of chromosome 7, and at the end of this segment is attached the deleted q11 leads to qter portion of chromosome 22. A review of 12 cases of the Philadelphia chromosome originating by the rearrangement of three or more chromosomes reveals that chromosomes 9 and 22 are always involved, while the third chromosome is a different one in each case. We discuss the hypothesis that the 22q segment is always specifically attached to band 9q34 wherever this portion of 9q is transposed.

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Mesh：

Year:  1978        PMID： 278772     DOI： 10.1007/bf00293590

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  6 in total

1.  Structural rearrangements associated with the Ph1 chromosome in chronic granulocytic leukaemia.

Authors:  A M Potter; J C Sharp; M J Brown; R J Sokol
Journal:  Humangenetik       Date:  1975-09-23

2.  Two complex translocations in chronic granulocytic leukemia involving chromosomes 22, 9, and a third chromosome.

Authors:  P C Nowell; J Jensen; F Gardner
Journal:  Humangenetik       Date:  1975-10-20

3.  Chronic myelocytic leukemia with a masked Ph1 chromosome.

Authors:  J Tanzer; Y Najean; C Frocrain; A Bernheim
Journal:  N Engl J Med       Date:  1977-03-10       Impact factor: 91.245

4.  A case of chronic myeloid leukemia with a translocation (12;22)(p13;q11).

Authors:  M van der Blij-Philipsen; W P Breed; T W Hustinx
Journal:  Hum Genet       Date:  1977-11-10       Impact factor: 4.132

5.  A new translocation involving three chromosomes in chronic myelocytic leukemia, 46,XY,t(9;11;22).

Authors:  G Gahrton; K Friberg; L Zech
Journal:  Cytogenet Cell Genet       Date:  1977

6.  Chromosomes and causation of human cancer and leukemia. XVI. Banding studies of chronic myelocytic leukemia, including five unusual Ph11 translocations.

Authors:  I Hayata; M Sakurai; S Kakati; A A Sandberg
Journal:  Cancer       Date:  1975-10       Impact factor: 6.860
  6 in total
  3 in total

1.  Transposition of 9q34 and 22 (q11toqter) regions has a specific role in chronic myelocytic leukemia.

Authors:  F Pasquali; R Casalone; D Francesconi; D Peretti; M Fraccaro; C Bernasconi; M Lazzarino
Journal:  Hum Genet       Date:  1979-11-01       Impact factor: 4.132

2.  Translocation between chromosome 7 and chromosome 22, t(7;22)(p22;q12), in a patient with chronic myelocytic leukemia.

Authors:  G Gahrton; K Friberg; L Zech
Journal:  Hum Genet       Date:  1979-06-19       Impact factor: 4.132

3.  New complex Ph' translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia.

Authors:  F Shabtai; U Gafter; S Weiss; M Djaldetti; I Halbrecht
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553
  3 in total

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