Brandon C Gabel1, Erik I Curtis2, Martin Marsala2, Joseph D Ciacci2. 1. Department of Neurosurgery, University of California, San Diego, San Diego, California, USA. Electronic address: bgabel@ucsd.edu. 2. Department of Neurosurgery, University of California, San Diego, San Diego, California, USA.
Abstract
OBJECTIVE: To review the literature of spinal cord injury and stem cell therapy for large animal models and incorporate those results into an understanding of stem cell therapy for human cord injury. METHODS: Review of the literature. RESULTS: Eleven canine studies were identified and 3 sub-human primate studies were identified showing variable results. CONCLUSIONS: Stem cell therapy is a promising therapeutic option for patients with spinal cord injury; however, the technology has many un-answered questions and further research is needed.
OBJECTIVE: To review the literature of spinal cord injury and stem cell therapy for large animal models and incorporate those results into an understanding of stem cell therapy for humancord injury. METHODS: Review of the literature. RESULTS: Eleven canine studies were identified and 3 sub-human primate studies were identified showing variable results. CONCLUSIONS: Stem cell therapy is a promising therapeutic option for patients with spinal cord injury; however, the technology has many un-answered questions and further research is needed.
Authors: Sabino Luzzi; Alberto Maria Crovace; Mattia Del Maestro; Alice Giotta Lucifero; Samer K Elbabaa; Benedetta Cinque; Paola Palumbo; Francesca Lombardi; Annamaria Cimini; Maria Grazia Cifone; Antonio Crovace; Renato Galzio Journal: Heliyon Date: 2019-11-26
Authors: Joseph A Shehadi; Steven M Elzein; Paul Beery; M Chance Spalding; Michelle Pershing Journal: Neural Regen Res Date: 2021-02 Impact factor: 5.135