| Literature DB >> 27876612 |
Daria Di Sabatino1, Gabriella Di Francesco1, Guendalina Zaccaria1, Daniela Malatesta1, Luca Brugnola2, Maurilia Marcacci1, Ottavio Portanti1, Fabrizio De Massis1, Giovanni Savini1, Liana Teodori1, Enzo Ruggieri1, Iolanda Mangone1, Pietro Badagliacca1, Alessio Lorusso3.
Abstract
Canine distemper virus (CDV) represents an important conservation threat to many wild carnivores. A large distemper epidemic sustained by an Arctic-lineage strain occurred in Italy in 2013, mainly in the Abruzzi region, causing overt disease in domestic and shepherd dogs, Apennine wolves (Canis lupus) and other wild carnivores. Two badgers were collected by the end of September 2015 in a rural area of the Abruzzi region and were demonstrated to be CDV-positive by real time RT-PCR and IHC in several tissues. The genome of CDV isolates from badgers showed Y549H substitution in the mature H protein. By employing all publicly available Arctic-lineage H protein encoding gene sequences, six amino acid changes in recent Italian strains with respect to Italian strains of dogs from 2000 to 2008, were observed. A CDV strain belonging to the European-wildlife lineage was also identified in a fox found dead in the same region in 2016, proving co-circulation of an additional CDV lineage. Copyright ÂEntities:
Keywords: Badgers; Canine distemper virus; Fox; Phylogeny; Whole genome sequencing; Wildlife
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Year: 2016 PMID： 27876612 DOI： 10.1016/j.meegid.2016.10.020
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342