Meredith E Giuliani1, Andrew Hope2, Victor Mangona3, Matthias Guckenberger4, Frederick Mantel5, Heike Peulen6, Jan-Jakob Sonke6, José Belderbos6, Maria Werner-Wasik7, Hong Ye3, Inga S Grills3. 1. Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada. Electronic address: meredith.giuliani@rmp.uhn.on.ca. 2. Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada. 3. Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI. 4. Department of Radiation Oncology, University of Zurich, Zurich, Switzerland; Department of Radiation Oncology, University of Wuerzburg, Wuerzburg, Germany. 5. Department of Radiation Oncology, University of Wuerzburg, Wuerzburg, Germany. 6. Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. 7. Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA.
Abstract
INTRODUCTION: The objective of this study was to determine the predictors and patterns of regional recurrence (RR) following stereotactic body radiotherapy (SBRT) for primary lung cancers. MATERIAL AND METHODS: Details of patient factors, treatment, and outcome factors were extracted from a multi-institutional (5) database. All events were calculated from the end of radiotherapy. Estimates of local recurrence, RR, and distant metastases (DM) were calculated using the competing risk method. Cause-specific and overall survival were calculated using the Kaplan-Meier method. Details of locations and number of simultaneous RRs were categorized by lymph node anatomic station. RESULTS: A total of 734 patients were analyzed. The median follow-up was 3.0 years in surviving patients. Four hundred seventy-six (65%) patients had pathologic proof of disease. There were 64 patients with RR. The 2-year local recurrence, RR, and distant metastases rates were 5.6%, 9.0%, and 14.6% respectively. The 2-year cause-specific and overall survival were 89.9% and 63.7%, respectively. There were 136 simultaneous sites of RR. There were 21 recurrences in stations 4R (15.4%), 9 (6.6%) in 4L, 30 (22%) in 7, 19 (13.9%) in 10R, and 14 (10.3%) in 10L. The most common stations for isolated recurrence (n = 19) were station 7 (n = 5; 26.3%) and station 10R (n = 6; 31.6%). The most common RR levels were stations 4 and 7 for right and left upper lobe, stations 5, 7, and 10 for left lower lobe tumors, and stations 7 and 10 for right lower lobe tumors. CONCLUSION: Stations 4, 7, and 10 were the most common stations for RR. These patterns of recurrence may guide nodal staging procedures prior to SBRT.
INTRODUCTION: The objective of this study was to determine the predictors and patterns of regional recurrence (RR) following stereotactic body radiotherapy (SBRT) for primary lung cancers. MATERIAL AND METHODS: Details of patient factors, treatment, and outcome factors were extracted from a multi-institutional (5) database. All events were calculated from the end of radiotherapy. Estimates of local recurrence, RR, and distant metastases (DM) were calculated using the competing risk method. Cause-specific and overall survival were calculated using the Kaplan-Meier method. Details of locations and number of simultaneous RRs were categorized by lymph node anatomic station. RESULTS: A total of 734 patients were analyzed. The median follow-up was 3.0 years in surviving patients. Four hundred seventy-six (65%) patients had pathologic proof of disease. There were 64 patients with RR. The 2-year local recurrence, RR, and distant metastases rates were 5.6%, 9.0%, and 14.6% respectively. The 2-year cause-specific and overall survival were 89.9% and 63.7%, respectively. There were 136 simultaneous sites of RR. There were 21 recurrences in stations 4R (15.4%), 9 (6.6%) in 4L, 30 (22%) in 7, 19 (13.9%) in 10R, and 14 (10.3%) in 10L. The most common stations for isolated recurrence (n = 19) were station 7 (n = 5; 26.3%) and station 10R (n = 6; 31.6%). The most common RR levels were stations 4 and 7 for right and left upper lobe, stations 5, 7, and 10 for left lower lobe tumors, and stations 7 and 10 for right lower lobe tumors. CONCLUSION: Stations 4, 7, and 10 were the most common stations for RR. These patterns of recurrence may guide nodal staging procedures prior to SBRT.
Authors: Alberto Cerra-Franco; Sheng Liu; Michella Azar; Kevin Shiue; Samantha Freije; Jason Hinton; Christopher R Deig; Donna Edwards; Neil C Estabrook; Susannah G Ellsworth; Ke Huang; Khalil Diab; Mark P Langer; Richard Zellars; Feng-Ming Kong; Jun Wan; Tim Lautenschlaeger Journal: Clin Lung Cancer Date: 2018-12-29 Impact factor: 4.785
Authors: Madison R Kocher; Anand Sharma; Elizabeth Garrett-Mayer; James G Ravenel Journal: J Comput Assist Tomogr Date: 2018 Jan/Feb Impact factor: 1.826
Authors: Susanne Stera; Panagiotis Balermpas; Mark K H Chan; Stefan Huttenlocher; Stefan Wurster; Christian Keller; Detlef Imhoff; Dirk Rades; Jürgen Dunst; Claus Rödel; Guido Hildebrandt; Oliver Blanck Journal: Strahlenther Onkol Date: 2017-09-05 Impact factor: 3.621
Authors: Adam R Belanger; Johnathan Hollyfield; Gabriella Yacovone; Agathe S Ceppe; Jason A Akulian; A Cole Burks; M Patricia Rivera; Leslie G Dodd; Jason M Long; Benjamin E Haithcock; Chad V Pecot Journal: J Thorac Dis Date: 2019-08 Impact factor: 2.895