BACKGROUND: The LifeLines Cohort Study is a large three-generation prospective study and Biobank. Recruitment and data collection started in 2006 and follow-up is planned for 30years. The central aim of LifeLines is to understand healthy ageing in the 21st century. Here, the study design, methods, baseline and major cardiovascular phenotypes of the LifeLines Cohort Study are presented. METHODS AND RESULTS: Baseline cardiovascular phenotypes were defined in 9700 juvenile (8-18years) and 152,180 adult (≥18years) participants. Cardiovascular disease (CVD) was defined using ICD-10 criteria. At least one cardiovascular risk factor was present in 73% of the adult participants. The prevalence, adjusted for the Dutch population, was determined for risk factors (hypertension (33%), hypercholesterolemia (19%), diabetes (4%), overweight (56%), and current smoking (19%)) and CVD (myocardial infarction (1.8%), heart failure (1.0%), and atrial fibrillation (1.3%)). Overall CVD prevalence increased with age from 9% in participants<65years to 28% in participants≥65years. Of the participants with hypertension, hypercholesterolemia and diabetes, respectively 75%, 96% and 41% did not receive preventive pharmacotherapy. CONCLUSIONS: The contemporary LifeLines Cohort Study provides researchers with unique and novel opportunities to study environmental, phenotypic, and genetic risk factors for CVD and is expected to improve our knowledge on healthy ageing. In this contemporary Western cohort we identified a remarkable high percentage of untreated CVD risk factors suggesting that not all opportunities to reduce the CVD burden are utilised.
BACKGROUND: The LifeLines Cohort Study is a large three-generation prospective study and Biobank. Recruitment and data collection started in 2006 and follow-up is planned for 30years. The central aim of LifeLines is to understand healthy ageing in the 21st century. Here, the study design, methods, baseline and major cardiovascular phenotypes of the LifeLines Cohort Study are presented. METHODS AND RESULTS: Baseline cardiovascular phenotypes were defined in 9700 juvenile (8-18years) and 152,180 adult (≥18years) participants. Cardiovascular disease (CVD) was defined using ICD-10 criteria. At least one cardiovascular risk factor was present in 73% of the adult participants. The prevalence, adjusted for the Dutch population, was determined for risk factors (hypertension (33%), hypercholesterolemia (19%), diabetes (4%), overweight (56%), and current smoking (19%)) and CVD (myocardial infarction (1.8%), heart failure (1.0%), and atrial fibrillation (1.3%)). Overall CVD prevalence increased with age from 9% in participants<65years to 28% in participants≥65years. Of the participants with hypertension, hypercholesterolemia and diabetes, respectively 75%, 96% and 41% did not receive preventive pharmacotherapy. CONCLUSIONS: The contemporary LifeLines Cohort Study provides researchers with unique and novel opportunities to study environmental, phenotypic, and genetic risk factors for CVD and is expected to improve our knowledge on healthy ageing. In this contemporary Western cohort we identified a remarkable high percentage of untreated CVD risk factors suggesting that not all opportunities to reduce the CVD burden are utilised.
Authors: M Yldau van der Ende; Joylene E Siland; Harold Snieder; Pim van der Harst; Michiel Rienstra Journal: Clin Cardiol Date: 2017-06-12 Impact factor: 2.882
Authors: Siying Zou; Alexandra M Teixeira; Myrto Kostadima; William J Astle; Aparna Radhakrishnan; Lukas Mikolaj Simon; Lucy Truman; Jennifer S Fang; John Hwa; Ping-Xia Zhang; Pim van der Harst; Paul F Bray; Willem H Ouwehand; Mattia Frontini; Diane S Krause Journal: PLoS One Date: 2017-05-23 Impact factor: 3.240
Authors: M Yldau van der Ende; Luis Eduardo Juarez-Orozco; Ingmar Waardenburg; Erik Lipsic; Remco A J Schurer; Hindrik W van der Werf; Emelia J Benjamin; Dirk Jan van Veldhuisen; Harold Snieder; Pim van der Harst Journal: J Am Heart Assoc Date: 2020-06-23 Impact factor: 5.501
Authors: Nastaran Salavati; Petra C Vinke; Fraser Lewis; Marian K Bakker; Jan Jaap H M Erwich; Eline M van der Beek Journal: Nutrients Date: 2020-10-16 Impact factor: 5.717
Authors: Manon J M van Oosten; Richard M Brohet; Susan J J Logtenberg; Anneke Kramer; Lambert D Dikkeschei; Marc H Hemmelder; Henk J G Bilo; Kitty J Jager; Vianda S Stel Journal: Clin Kidney J Date: 2020-11-09