Literature DB >> 27875677

A Case Report of Pregnancy During Use of Targeted Therapeutics for Cystic Fibrosis.

Sigrid Ladores, Traci M Kazmerski, Steven M Rowe.   

Abstract

New therapeutics, such as ivacaftor, and the combination drug lumacaftor/ivacaftor that target the underlying genetic cause of cystic fibrosis are being hailed as game-changers in this era of personalized medicine. Although these drugs improve lung function, their effects on female fertility have not been studied. In this case report we describe one woman's experience with ivacaftor and her unanticipated pregnancy. Implications related to comprehensive sexual and reproductive health care for women with cystic fibrosis are presented.
Copyright © 2017 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cystic fibrosis; fertility; ivacaftor; lumacaftor/ivacaftor; sexual and reproductive health

Mesh：

Substances：

Year:  2016        PMID： 27875677     DOI： 10.1016/j.jogn.2016.08.011

Source DB:  PubMed          Journal:  J Obstet Gynecol Neonatal Nurs        ISSN： 0090-0311


  5 in total

1.  Measured fetal and neonatal exposure to Lumacaftor and Ivacaftor during pregnancy and while breastfeeding.

Authors:  Aaron Trimble; Cameron McKinzie; Mary Terrell; Elizabeth Stringer; Charles R Esther
Journal:  J Cyst Fibros       Date:  2018-06-01       Impact factor: 5.482

Review 2.  Challenges in the use of highly effective modulator treatment for cystic fibrosis.

Authors:  Kathleen J Ramos; Joseph M Pilewski; Jennifer L Taylor-Cousar
Journal:  J Cyst Fibros       Date:  2021-01-30       Impact factor: 5.482

3.  Two Unanticipated Pregnancies While on Cystic Fibrosis Gene-Specific Drug Therapy.

Authors:  Sigrid Ladores; Leigh Ann Bray; Janet Brown
Journal:  J Patient Exp       Date:  2019-11-26

Review 4.  Fertility, Pregnancy and Lactation Considerations for Women with CF in the CFTR Modulator Era.

Authors:  Raksha Jain; Jennifer L Taylor-Cousar
Journal:  J Pers Med       Date:  2021-05-15

Review 5.  The Extrapulmonary Effects of Cystic Fibrosis Transmembrane Conductance Regulator Modulators in Cystic Fibrosis.

Authors:  Valentine Sergeev; Frank Y Chou; Grace Y Lam; Christopher Michael Hamilton; Pearce G Wilcox; Bradley S Quon
Journal:  Ann Am Thorac Soc       Date:  2020-02
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.