PURPOSE: Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple-transgenic AD (3xTg-AD) mice. METHODS: The 3xTg-AD mice were assigned to a chow diet (control, n = 10), an HFD (n = 10), or an HFD combined with exercise (HFD + EX, n = 10) group. Mice in the HFD were fed with a 60% fat diet for 20 wk. The HFD + EX mice were additionally subjected to treadmill running. RESULTS: Compared with the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD + EX mice. CONCLUSION: The current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by an HFD in the 3xTg-AD mice.
PURPOSE: Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple-transgenic AD (3xTg-AD) mice. METHODS: The 3xTg-ADmice were assigned to a chow diet (control, n = 10), an HFD (n = 10), or an HFD combined with exercise (HFD + EX, n = 10) group. Mice in the HFD were fed with a 60% fat diet for 20 wk. The HFD + EX mice were additionally subjected to treadmill running. RESULTS: Compared with the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD + EX mice. CONCLUSION: The current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by an HFD in the 3xTg-ADmice.
Authors: Olivia J Gannon; Lisa S Robison; Abigail E Salinero; Charly Abi-Ghanem; Febronia M Mansour; Richard D Kelly; Alvira Tyagi; Rebekah R Brawley; Jordan D Ogg; Kristen L Zuloaga Journal: J Neuroinflammation Date: 2022-05-14 Impact factor: 9.587
Authors: Thomas S Webberley; Giulia Masetti; Ryan J Bevan; Joshua Kerry-Smith; Alison A Jack; Daryn R Michael; Sophie Thomas; Maria Glymenaki; Jia Li; Julie A K McDonald; Daniel John; James E Morgan; Julian R Marchesi; Mark A Good; Sue F Plummer; Timothy R Hughes Journal: Front Neurosci Date: 2022-05-24 Impact factor: 5.152
Authors: Su Jin Lee; Ji Eun Kim; Yun Ju Choi; Jeong Eun Gong; So Hae Park; Bounleuane Douangdeuane; Onevilay Souliya; Ju Min Park; Hee Seob Lee; Bae-Hwan Kim; Dae Youn Hwang Journal: Antioxidants (Basel) Date: 2021-05-17
Authors: Hyeon Jun Choi; Bo Ram Song; Ji Eun Kim; Su Ji Bae; Yun Ju Choi; Su Jin Lee; Jeong Eun Gong; Hee Seob Lee; Chung Yeoul Lee; Bae-Hwan Kim; Dae Youn Hwang Journal: Molecules Date: 2020-02-22 Impact factor: 4.411