Elisabet Wentz1, Anna Björk2, Jovanna Dahlgren2. 1. Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Göteborg, Sweden. 2. Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Göteborg, Sweden.
Abstract
OBJECTIVE: To investigate prevalence of neurodevelopmental disorders in children with obesity and to compare body mass index (BMI) and metabolic profile in the children. METHODS: Seventy-six children (37 girls, 39 boys) were consecutively recruited from a university outpatient clinic specialized in severe obesity. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental coordination disorder (DCD) were assessed using interviews and questionnaires. Neurodevelopmental diagnoses were collected retrospectively in medical records. RESULTS: BMI ranged between 1.9 and 5.9 SDS and age between 5.1 and 16.5 years. In 13.2% and 18.4% ASD and ADHD was assigned, respectively. In addition, 25% screened positive for DCD, 31.6% had at least one neurodevelopmental disorder, and 18.4% had a parent who screened positive for adult ADHD. Girls with ASD/ADHD had higher BMI SDS than girls without neurodevelopmental disorder (P = 0.006). CONCLUSIONS: One third of children with obesity referred to specialist centers have a neurodevelopmental disorder including deviant motor skills, and these problems may deteriorate weight status. One fifth of the parents exhibit ADHD symptomatology which could partly explain the poor adherence by some families in obesity units. Future obesity therapy could benefit from incorporating a neurodevelopmental treatment approach.
OBJECTIVE: To investigate prevalence of neurodevelopmental disorders in children with obesity and to compare body mass index (BMI) and metabolic profile in the children. METHODS: Seventy-six children (37 girls, 39 boys) were consecutively recruited from a university outpatient clinic specialized in severe obesity. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental coordination disorder (DCD) were assessed using interviews and questionnaires. Neurodevelopmental diagnoses were collected retrospectively in medical records. RESULTS: BMI ranged between 1.9 and 5.9 SDS and age between 5.1 and 16.5 years. In 13.2% and 18.4% ASD and ADHD was assigned, respectively. In addition, 25% screened positive for DCD, 31.6% had at least one neurodevelopmental disorder, and 18.4% had a parent who screened positive for adult ADHD. Girls with ASD/ADHD had higher BMI SDS than girls without neurodevelopmental disorder (P = 0.006). CONCLUSIONS: One third of children with obesity referred to specialist centers have a neurodevelopmental disorder including deviant motor skills, and these problems may deteriorate weight status. One fifth of the parents exhibit ADHD symptomatology which could partly explain the poor adherence by some families in obesity units. Future obesity therapy could benefit from incorporating a neurodevelopmental treatment approach.
Authors: Narendra K Arora; M K C Nair; Sheffali Gulati; Vaishali Deshmukh; Archisman Mohapatra; Devendra Mishra; Vikram Patel; Ravindra M Pandey; Bhagabati C Das; Gauri Divan; G V S Murthy; Thakur D Sharma; Savita Sapra; Satinder Aneja; Monica Juneja; Sunanda K Reddy; Praveen Suman; Sharmila B Mukherjee; Rajib Dasgupta; Poma Tudu; Manoja K Das; Vinod K Bhutani; Maureen S Durkin; Jennifer Pinto-Martin; Donald H Silberberg; Rajesh Sagar; Faruqueuddin Ahmed; Nandita Babu; Sandeep Bavdekar; Vijay Chandra; Zia Chaudhuri; Tanuj Dada; Rashna Dass; M Gourie-Devi; S Remadevi; Jagdish C Gupta; Kumud K Handa; Veena Kalra; Sunil Karande; Ramesh Konanki; Madhuri Kulkarni; Rashmi Kumar; Arti Maria; Muneer A Masoodi; Manju Mehta; Santosh Kumar Mohanty; Harikumaran Nair; Poonam Natarajan; A K Niswade; Atul Prasad; Sanjay K Rai; Paul S S Russell; Rohit Saxena; Shobha Sharma; Arun K Singh; Gautam B Singh; Leena Sumaraj; Saradha Suresh; Alok Thakar; Sujatha Parthasarathy; Bhadresh Vyas; Ansuman Panigrahi; Munish K Saroch; Rajan Shukla; K V Raghava Rao; Maria P Silveira; Samiksha Singh; Vivek Vajaratkar Journal: PLoS Med Date: 2018-07-24 Impact factor: 11.069
Authors: Maria Caterina De Rosa; Hannah J Glover; George Stratigopoulos; Charles A LeDuc; Qi Su; Yufeng Shen; Mark W Sleeman; Wendy K Chung; Rudolph L Leibel; Judith Y Altarejos; Claudia A Doege Journal: JCI Insight Date: 2021-08-23