Esther Via1,2,3,4, Ximena Goldberg1,4,5, Isabel Sánchez1, Laura Forcano6,7, Ben J Harrison3, Christopher G Davey3,8, Jesús Pujol9, Ignacio Martínez-Zalacaín1, Fernando Fernández-Aranda1,2,7, Carles Soriano-Mas1,5,10, Narcís Cardoner4,11, José M Menchón1,2,5. 1. a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain. 2. b Department of Clinical Sciences , School of Medicine, University of Barcelona , Barcelona , Spain. 3. c Melbourne Neuropsychiatry Centre, The Department of Psychiatry , The University of Melbourne , Melbourne , Australia. 4. d Depression and Anxiety Program, Mental Health Department , Parc Taulí Sabadell University Hospital , Barcelona , Spain. 5. e CIBER Salud Mental (CIBERSAM) , Instituto de Salud Carlos III , Barcelona , Spain. 6. f Clinical research group in human pharmacology and neuroscience , IMIM Research Institute at the Hospital de Mar , Barcelona , Spain. 7. g CIBER Fisiopatología Obesidad y Nutrición (CIBERObn) , Instituto de Salud Carlos III , Barcelona , Spain. 8. h Orygen, The National Centre of Excellence in Youth Mental Health , Melbourne , Australia. 9. i MRI Research Unit , Hospital del Mar, CIBERSAM G21 , Barcelona , Spain. 10. j Department of Psychobiology and Methodology in Health Sciences , Universitat Autònoma de Barcelona , Spain. 11. k Department of Psychiatry , Universitat Autònoma de Barcelona , Spain.
Abstract
OBJECTIVES: Body image distortion is a core symptom of anorexia nervosa (AN), which involves alterations in self- (and other's) evaluative processes arising during body perception. At a neural level, self-related information is thought to rely on areas of the so-called default mode network (DMN), which, additionally, shows prominent synchronised activity at rest. METHODS: Twenty female patients with AN and 20 matched healthy controls were scanned using magnetic resonance imaging when: (a) viewing video clips of their own body and another's body; (b) at rest. Between-group differences within the DMN during task performance were evaluated and further explored for task-related and resting-state-related functional connectivity alterations. RESULTS: AN patients showed a hyperactivation of the dorsal posterior cingulate cortex during their own-body processing but a response failure to another's body processing at the precuneus and ventral PCC. Increased task-related connectivity was found between dPCC-dorsal anterior cingulate cortex and precuneus-mid-temporal cortex. Further, AN patients showed decreased resting-state connectivity between the dPCC and the angular gyrus. CONCLUSIONS: The PCC and the precuneus are suggested as key components of a network supporting self-other-evaluative processes implicated in body distortion, while the existence of DMN alterations at rest might reflect a sustained, task-independent breakdown within this network in AN.
OBJECTIVES: Body image distortion is a core symptom of anorexia nervosa (AN), which involves alterations in self- (and other's) evaluative processes arising during body perception. At a neural level, self-related information is thought to rely on areas of the so-called default mode network (DMN), which, additionally, shows prominent synchronised activity at rest. METHODS: Twenty female patients with AN and 20 matched healthy controls were scanned using magnetic resonance imaging when: (a) viewing video clips of their own body and another's body; (b) at rest. Between-group differences within the DMN during task performance were evaluated and further explored for task-related and resting-state-related functional connectivity alterations. RESULTS: AN patients showed a hyperactivation of the dorsal posterior cingulate cortex during their own-body processing but a response failure to another's body processing at the precuneus and ventral PCC. Increased task-related connectivity was found between dPCC-dorsal anterior cingulate cortex and precuneus-mid-temporal cortex. Further, AN patients showed decreased resting-state connectivity between the dPCC and the angular gyrus. CONCLUSIONS: The PCC and the precuneus are suggested as key components of a network supporting self-other-evaluative processes implicated in body distortion, while the existence of DMN alterations at rest might reflect a sustained, task-independent breakdown within this network in AN.
Entities:
Keywords:
Anorexia nervosa; body image; fMRI; resting state; self-evaluation
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