Diane Pourchot1, Christine Bodemer2, Alice Phan3, Anne-Claire Bursztejn4, Smaïl Hadj-Rabia2, Franck Boralevi5, Juliette Miquel6, Thomas Hubiche7, Eve Puzenat8, Anne-Laure Souillet3, Ingrid Kupfer9, Maryam Piram10, Alain Beauchet11, Emmanuel Mahé1. 1. Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France. 2. Service de Dermatologie, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris-Descartes Sorbonne Paris Cité, Paris, France. 3. Service de Néphro-Rhumato-Dermatologie pédiatrique, Hôpital Femme-Mère-Enfant, Bron, France. 4. Service de Dermatologie, Hôpital Brabois, Vandœuvre Les Nancy, France. 5. Unité de Dermatologie Pédiatrique, Hôpital Pellegrin-Enfants, Bordeaux, France. 6. Service de Dermatologie, Centre Hospitalier Universitaire Pontchaillou, Rennes, France. 7. Unité de Dermatologie Infectiologie, Centre Hospitalier Intercommunal de Fréjus/Saint-Raphaël, Fréjus, France. 8. Service de Dermatologie, Centre Hospitalier Universitaire Saint-Jacques, Besançon, France. 9. Service de Dermatologie, Centre Hospitalier de Cornouaille, Quimper, France. 10. Service de Rhumatologie Pédiatrique, CeRéMAI, Université Paris Sud, Centre Hospitalier Universitaire de Bicêtre, Le Kremlin-Bicêtre, France. 11. Département de Santé Publique, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Ambroise Paré, Université Versailles-Saint-Quentin-en-Yvelines, Boulogne-Billancourt, France.
Abstract
BACKGROUND/ OBJECTIVES: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis. METHODS: We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included. Clinical features of the nails were collected. Association with clinical aspects of the disease and comorbidities were evaluated. RESULTS: Of 313 children with psoriasis (mean age 9.1 ± 4.2 yrs; 149 boys, 164 girls), 31.1% had familial psoriasis and 30% had severe psoriasis. The mean age at onset was 6.1 ± 3.7 years. Nails were involved in 32.3% of children. The main clinical aspects were pitting (69.1%) for fingernails and onycholysis (40.0%) and pachyonychia (27.5%) for toenails. All of the fingers were involved at similar frequencies, whereas the big toe was involved twice as often as the others (p < 0.005). Nail involvement was associated with male sex (p < 0.001), palmoplantar psoriatic (p < 0.001), severity of disease (p = 0.003), and psoriatic arthritis (p = 0.03). CONCLUSION: The prevalence of nail involvement was 32.3% in children with psoriasis. Clinical aspects in children are reported, as well as clinical associations. As in adults, nail psoriasis is closely associated with psoriatic arthritis.
BACKGROUND/ OBJECTIVES: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis. METHODS: We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included. Clinical features of the nails were collected. Association with clinical aspects of the disease and comorbidities were evaluated. RESULTS: Of 313 children with psoriasis (mean age 9.1 ± 4.2 yrs; 149 boys, 164 girls), 31.1% had familial psoriasis and 30% had severe psoriasis. The mean age at onset was 6.1 ± 3.7 years. Nails were involved in 32.3% of children. The main clinical aspects were pitting (69.1%) for fingernails and onycholysis (40.0%) and pachyonychia (27.5%) for toenails. All of the fingers were involved at similar frequencies, whereas the big toe was involved twice as often as the others (p < 0.005). Nail involvement was associated with male sex (p < 0.001), palmoplantar psoriatic (p < 0.001), severity of disease (p = 0.003), and psoriatic arthritis (p = 0.03). CONCLUSION: The prevalence of nail involvement was 32.3% in children with psoriasis. Clinical aspects in children are reported, as well as clinical associations. As in adults, nailpsoriasis is closely associated with psoriatic arthritis.
Authors: Bhumesh Kumar Katakam; Malathi Munisamy; T Narayana Rao; Minu Jose Chiramel; Maitreyee Panda; Sandeep Gupta; Ranugha Pss; K A Seetharam Journal: Indian Dermatol Online J Date: 2021-11-25