Hidenobu Hashimoto1,2, Yoshimitsu Fukushima3, Shin-Ichiro Kumita3, Masaaki Miyamoto4, Gen Takagi4, Junichi Yamazaki5, Takanori Ikeda5. 1. Department of Cardiovascular Medicine, Faculty of Medicine, Toho University, 6-11-1, Omorinishi, Ota, Tokyo, 143-8541, Japan. hidenobu.hashimoto@med.toho-u.ac.jp. 2. Department of Radiology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo, Tokyo, 113-8603, Japan. hidenobu.hashimoto@med.toho-u.ac.jp. 3. Department of Radiology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo, Tokyo, 113-8603, Japan. 4. Department of Internal Medicine, Division of Cardiovascular and Regenerative Medicine, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo, Tokyo, 113-8603, Japan. 5. Department of Cardiovascular Medicine, Faculty of Medicine, Toho University, 6-11-1, Omorinishi, Ota, Tokyo, 143-8541, Japan.
Abstract
PURPOSE: The purpose of this study was to estimate the severity of the participants' lower limb ischemia by calculating the lower limb muscle-to-background ratio (LMBR) using lower limb perfusion single-photon emission computed tomography-computed tomography (SPECT/CT) and to evaluate the prognostic value of LMBR in peripheral artery disease (PAD) patients. MATERIALS AND METHODS: This retrospective study consists of 38 patients with PAD (70 ± 12 years) and observed over 1 year who were included in the analysis. All participants underwent lower limb perfusion SPECT/CT. LMBR was calculated by dividing counts/volume in lower limb muscle by mean counts/volume of background. All patients were divided into two groups based on their LMBR value and observed for the occurrence of a major adverse event (MAE). RESULTS: The high and low LMBR groups consisted of 26 and 12 patients, respectively. The median LMBR in the high group was 9.59 (6.11-11.87) while that in the low group was 4.35 (3.85-4.99). A significantly higher number of patients in the low LMBR group experienced MAE than in the high LMBR group (7 of 12 vs. 1 of 26, p < 0.001). CONCLUSION: This study demonstrated that the LMBR derived from lower limb perfusion SPECT/CT may have a high prognostic value in patients with PAD.
PURPOSE: The purpose of this study was to estimate the severity of the participants' lower limb ischemia by calculating the lower limb muscle-to-background ratio (LMBR) using lower limb perfusion single-photon emission computed tomography-computed tomography (SPECT/CT) and to evaluate the prognostic value of LMBR in peripheral artery disease (PAD) patients. MATERIALS AND METHODS: This retrospective study consists of 38 patients with PAD (70 ± 12 years) and observed over 1 year who were included in the analysis. All participants underwent lower limb perfusion SPECT/CT. LMBR was calculated by dividing counts/volume in lower limb muscle by mean counts/volume of background. All patients were divided into two groups based on their LMBR value and observed for the occurrence of a major adverse event (MAE). RESULTS: The high and low LMBR groups consisted of 26 and 12 patients, respectively. The median LMBR in the high group was 9.59 (6.11-11.87) while that in the low group was 4.35 (3.85-4.99). A significantly higher number of patients in the low LMBR group experienced MAE than in the high LMBR group (7 of 12 vs. 1 of 26, p < 0.001). CONCLUSION: This study demonstrated that the LMBR derived from lower limb perfusion SPECT/CT may have a high prognostic value in patients with PAD.
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