Literature DB >> 27873089

Gut Hormone Regulation and Secretion via FFA1 and FFA4.

Fiona M Gribble1, Eleftheria Diakogiannaki2, Frank Reimann2.   

Abstract

The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatty acid receptors FFA1 and FFA4, which are highly expressed on enteroendocrine cells. These receptors are activated when free fatty acids (FFA) are absorbed across the intestinal epithelium, and provide a dynamic hormonal signal indicating that lipids are arriving in the bloodstream from the gut. This review addresses our current knowledge of how ingested triglycerides modulate gut hormone release via FFA1 and FFA4.

Entities:  

Keywords:  CCK; FFA1; FFA4; GIP; GLP-1; Ghrelin; Incretin

Mesh：

Substances：

Year:  2017        PMID： 27873089     DOI： 10.1007/164_2016_46

Source DB:  PubMed          Journal:  Handb Exp Pharmacol        ISSN： 0171-2004


  7 in total

Review 1.  Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology.

Authors:  Medha Priyadarshini; Kumar U Kotlo; Pradeep K Dudeja; Brian T Layden
Journal:  Compr Physiol       Date:  2018-06-18       Impact factor: 9.090

Review 2.  Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.

Authors:  J J Worthington; F Reimann; F M Gribble
Journal:  Mucosal Immunol       Date:  2017-08-30       Impact factor: 7.313

Review 3.  GLP-1: Molecular mechanisms and outcomes of a complex signaling system.

Authors:  Nicholas K Smith; Troy A Hackett; Aurelio Galli; Charles R Flynn
Journal:  Neurochem Int       Date:  2019-04-17       Impact factor: 3.921

4.  Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine.

Authors:  Leslie L Glass; Fernando J Calero-Nieto; Wajid Jawaid; Pierre Larraufie; Richard G Kay; Berthold Göttgens; Frank Reimann; Fiona M Gribble
Journal:  Mol Metab       Date:  2017-08-01       Impact factor: 7.422

5.  Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture.

Authors:  Deborah A Goldspink; Van B Lu; Emily L Miedzybrodzka; Christopher A Smith; Rachel E Foreman; Lawrence J Billing; Richard G Kay; Frank Reimann; Fiona M Gribble
Journal:  Cell Rep       Date:  2020-06-30       Impact factor: 9.423

Review 6.  Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies.

Authors:  Fiona M Gribble; Claire L Meek; Frank Reimann
Journal:  Peptides       Date:  2018-02       Impact factor: 3.750

Review 7.  Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes.

Authors:  Angelo Maria Patti; Rosaria Vincenza Giglio; Nikolaos Papanas; Dragos Serban; Anca Pantea Stoian; Kalliopi Pafili; Khalid Al Rasadi; Kanya Rajagopalan; Ali A Rizvi; Marcello Ciaccio; Manfredi Rizzo
Journal:  Medicina (Kaunas)       Date:  2022-01-11       Impact factor: 2.430
  7 in total

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