Literature DB >> 27872906

Sequence-specific recognition of methylated DNA by an engineered transcription activator-like effector protein.

Shogo Tsuji1, Shiroh Futaki1, Miki Imanishi1.   

Abstract

A 5mC-selective TALE-repeat was created by screening a TALE repeat library containing randomized amino acids at repeat variable diresidues and their neighboring residues. The new repeat showed high 5mC discrimination ability. An artificial TALE containing the new repeat activated an endogenous gene in a genomic methylation status-dependent manner.

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Year:  2016        PMID： 27872906     DOI： 10.1039/c6cc06824c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Designer Receptors for Nucleotide-Resolution Analysis of Genomic 5-Methylcytosine by Cellular Imaging.

Authors:  Álvaro Muñoz-López; Benjamin Buchmuller; Jan Wolffgramm; Anne Jung; Michelle Hussong; Julian Kanne; Michal R Schweiger; Daniel Summerer
Journal:  Angew Chem Int Ed Engl       Date:  2020-04-07       Impact factor: 15.336

Review 2.  CRISPR-Cas-mediated transcriptional control and epi-mutagenesis.

Authors:  Jason Gardiner; Basudev Ghoshal; Ming Wang; Steven E Jacobsen
Journal:  Plant Physiol       Date:  2022-03-28       Impact factor: 8.340

3.  Engineered TALE Repeats for Enhanced Imaging-Based Analysis of Cellular 5-Methylcytosine.

Authors:  Álvaro Muñoz-López; Anne Jung; Benjamin Buchmuller; Jan Wolffgramm; Sara Maurer; Anna Witte; Daniel Summerer
Journal:  Chembiochem       Date:  2020-11-06       Impact factor: 3.164
  3 in total

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