E Osei1, H M den Hertog2, O A Berkhemer3, P S S Fransen4, Y B W E M Roos5, D Beumer6, R J van Oostenbrugge7, W J Schonewille8, J Boiten9, A A M Zandbergen10, P J Koudstaal11, D W J Dippel12. 1. Medisch Spectrum Twente, Haaksbergerstraat 55, 7513ER Enschede, The Netherlands. Electronic address: e.osei@mst.nl. 2. Medisch Spectrum Twente, Haaksbergerstraat 55, 7513ER Enschede, The Netherlands. Electronic address: m.denhertog@mst.nl. 3. Academisch Medisch Centrum, Postbus 22660, 1100 DD Amsterdam, The Netherlands. Electronic address: o.a.berkhemer@amc.uva.nl. 4. Erasmus Medisch Centrum, Postbus 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: p.fransen@erasmusmc.nl. 5. Academisch Medisch Centrum, Postbus 22660, 1100 DD Amsterdam, The Netherlands. Electronic address: y.b.roos@amc.uva.nl. 6. Maastricht Universitair Medisch Centrum, Postbus 5800, 6202 AZ Maastricht, The Netherlands. Electronic address: debbie.beumer@mumc.nl. 7. Maastricht Universitair Medisch Centrum, Postbus 5800, 6202 AZ Maastricht, The Netherlands. Electronic address: r.van.oostenbrugge@mumc.nl. 8. St. Antonius Ziekenhuis, Postbus 2500, 3430 EM Nieuwegein, The Netherlands. Electronic address: w.schonewille@antoniusziekenhuis.nl. 9. Medisch Centrum Haaglanden, Postbus 432, 2501 CK Den Haag, The Netherlands. Electronic address: j.boiten@mchaaglanden.nl. 10. Ikazia Ziekenhuizen, Postbus 5009, 3008 AA Rotterdam, The Netherlands. Electronic address: aam.zandbergen@ikazia.nl. 11. Erasmus Medisch Centrum, Postbus 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: p.j.koudstaal@erasmusmc.nl. 12. Erasmus Medisch Centrum, Postbus 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: d.dippel@erasmusmc.nl.
Abstract
BACKGROUND: Limited data are available on the impact of fasting glucose on outcome after intra-arterial treatment (IAT). We studied whether hyperglycemia on admission and impaired fasting glucose (IFG) are associated with unfavorable outcome after IAT in acute ischemic stroke. METHODS: Patients were derived from the pretrial registry of the MR CLEAN-trial. Hyperglycemia on admission was defined as glucose>7.8mmol/L, IFG as fasting glucose>5.5mmol/L in the first week of admission. Primary effect measure was the adjusted common odds ratio (acOR) for a shift in the direction of worse outcome on the modified Rankin Scale at discharge, estimated with ordinal logistic regression, adjusted for common prognostic factors. RESULTS: Of the 335 patients in which glucose on admission was available, 86 (26%) were hyperglycemic, 148 of the 240 patients with available fasting glucose levels (62%) had IFG. Median admission glucose was 6.8mmol/L (IQR 6-8). Increased admission glucose (acOR 1.2, 95%CI 1.1-1.3), hyperglycemia on admission (acOR 2.6, 95%CI 1.5-4.6) and IFG (acOR 2.8, 95%CI 1.4-5.6) were associated with worse functional outcome at discharge. CONCLUSION:Increased glucose on admission and IFG in the first week after stroke onset are associated with unfavorable short-term outcome after IAT of acute ischemic stroke.
RCT Entities:
BACKGROUND: Limited data are available on the impact of fasting glucose on outcome after intra-arterial treatment (IAT). We studied whether hyperglycemia on admission and impaired fasting glucose (IFG) are associated with unfavorable outcome after IAT in acute ischemic stroke. METHODS:Patients were derived from the pretrial registry of the MR CLEAN-trial. Hyperglycemia on admission was defined as glucose>7.8mmol/L, IFG as fasting glucose>5.5mmol/L in the first week of admission. Primary effect measure was the adjusted common odds ratio (acOR) for a shift in the direction of worse outcome on the modified Rankin Scale at discharge, estimated with ordinal logistic regression, adjusted for common prognostic factors. RESULTS: Of the 335 patients in which glucose on admission was available, 86 (26%) were hyperglycemic, 148 of the 240 patients with available fasting glucose levels (62%) had IFG. Median admission glucose was 6.8mmol/L (IQR 6-8). Increased admission glucose (acOR 1.2, 95%CI 1.1-1.3), hyperglycemia on admission (acOR 2.6, 95%CI 1.5-4.6) and IFG (acOR 2.8, 95%CI 1.4-5.6) were associated with worse functional outcome at discharge. CONCLUSION: Increased glucose on admission and IFG in the first week after stroke onset are associated with unfavorable short-term outcome after IAT of acute ischemic stroke.
Authors: Jason Siegel; Michael A Pizzi; J Brent Peel; David Alejos; Nnenne Mbabuike; Benjamin L Brown; David Hodge; W David Freeman Journal: Curr Cardiol Rep Date: 2017-08 Impact factor: 2.931
Authors: Kotryna Genceviciute; Martina B Göldlin; Christoph C Kurmann; Adnan Mujanovic; Thomas R Meinel; Johannes Kaesmacher; David J Seiffge; Simon Jung; Pasquale Mordasini; Urs Fischer; Jan Gralla; Hakan Sarikaya; Barbara Goeggel Simonetti; Kateryna Antonenko; Roza M Umarova; Lia Bally; Marcel Arnold; Mirjam R Heldner Journal: Eur J Neurol Date: 2022-07-01 Impact factor: 6.288