Hosseinali Khalili1, Amin Niakan2, Fariborz Ghaffarpasand3. 1. Shiraz Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2. Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran. 3. Student Research Committee, Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: fariborz.ghaffarpasand@gmail.com.
Abstract
OBJECTIVE: To determine the effects of cerebrolysin on functional recovery in patients with severe disability after traumatic brain injury (TBI). METHODS: This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma. We excluded those with posttraumatic seizures and those with meningitis or current infections. Some patients received cerebrolysin (n=65) and some did not (n=64). Cerebrolysin was administered intravenously in 10mL dosage daily for 30days. Patients in two study groups were matched regarding the baseline characteristics including age, gender, GCS on admission, pupil reactivity and Rotterdam score. The administered cerebrolysin dosage was 10mL intravenously daily for 30days. The 3- and 6-month Glasgow Outcome Scale Extended (GOSE) was recorded. The outcome scales were compared between two study groups. RESULTS: Overall we included 129 patients with severe disability 1-month after TBI. The baseline characteristics were comparable between groups. We found that GOSE at 3-month (p=0.017) and 6-month (p=0.009) was significantly higher in those receiving cerebrolysin. Cerebrolysin administration was associated with lower mortality rate, and higher good recovery after 6 month of therapy (p=0.024). Cerebrolysin administration was also associated with higher favorable and lower unfavorable outcome (p=0.043). Cerebrolysin was associated with higher seizure rate (p=0.042). CONCLUSION: Cerebrolysin administration in patients with severe disability after TBI is associated with improved functional recovery, decreased mortality rate and increased favorable outcome. Seizure is important side effect of cerebrolysin administration in TBI patients.
OBJECTIVE: To determine the effects of cerebrolysin on functional recovery in patients with severe disability after traumatic brain injury (TBI). METHODS: This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma. We excluded those with posttraumatic seizures and those with meningitis or current infections. Some patients received cerebrolysin (n=65) and some did not (n=64). Cerebrolysin was administered intravenously in 10mL dosage daily for 30days. Patients in two study groups were matched regarding the baseline characteristics including age, gender, GCS on admission, pupil reactivity and Rotterdam score. The administered cerebrolysin dosage was 10mL intravenously daily for 30days. The 3- and 6-month Glasgow Outcome Scale Extended (GOSE) was recorded. The outcome scales were compared between two study groups. RESULTS: Overall we included 129 patients with severe disability 1-month after TBI. The baseline characteristics were comparable between groups. We found that GOSE at 3-month (p=0.017) and 6-month (p=0.009) was significantly higher in those receiving cerebrolysin. Cerebrolysin administration was associated with lower mortality rate, and higher good recovery after 6 month of therapy (p=0.024). Cerebrolysin administration was also associated with higher favorable and lower unfavorable outcome (p=0.043). Cerebrolysin was associated with higher seizure rate (p=0.042). CONCLUSION: Cerebrolysin administration in patients with severe disability after TBI is associated with improved functional recovery, decreased mortality rate and increased favorable outcome. Seizure is important side effect of cerebrolysin administration in TBI patients.
Authors: Peter Y M Woo; Joanna W K Ho; Natalie M W Ko; Ronald P T Li; Leo Jian; Alberto C H Chu; Marco C L Kwan; Yung Chan; Alain K S Wong; Hoi-Tung Wong; Kwong-Yau Chan; John C K Kwok Journal: BMC Neurol Date: 2020-11-03 Impact factor: 2.474
Authors: Dong Hyeon Kang; Bo Young Choi; Song Hee Lee; A Ra Kho; Jeong Hyun Jeong; Dae Ki Hong; Beom Seok Kang; Min Kyu Park; Hong Ki Song; Hui Chul Choi; Man-Sup Lim; Sang Won Suh Journal: Front Neurosci Date: 2020-10-16 Impact factor: 4.677