| Literature DB >> 27869276 |
F Trusch1, K Kowski2, K Bravo-Rodriguez3, C Beuck1, A Sowislok2, B Wettig2, A Matena1, E Sanchez-Garcia3, H Meyer4, T Schrader2, P Bayer1.
Abstract
Molecular tweezers for lysine and arginine select a few residues on a protein surface and by their unique complexation mode disrupt a critical protein-protein interaction. Detailed structural information was gained by NMR experiments, strongly supported by QM/MM calculations and further substantiated by ITC, fluorescence anisotropy, ELISA and bio-layer-interference studies.Entities:
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Year: 2016 PMID： 27869276 DOI： 10.1039/c6cc08039a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222