Literature DB >> 2786828

Novel carbenicillin-hydrolyzing beta-lactamase (CARB-5) from Acinetobacter calcoaceticus var. anitratus.

G Paul1, M L Joly-Guillou, E Bergogne-Berezin, P Névot, A Philippon.   

Abstract

A strain of Acinetobacter calcoaceticus var. anitratus highly resistant to ticarcillin but susceptible to ticarcillin in combination with clavulanic acid (2 mg/l) was found to produce a constitutive beta-lactamase. This enzyme was periplasmic with a characteristic substrate profile of a carbenicillin-hydrolyzing enzyme. Enzyme inhibition was detected with antiserum (anti-CARB-3), pCMB, cloxacillin, clavulanic acid and sulbactam. This novel enzyme with a molecular mass of 28,000 resembles other plasmid-mediated carbenicillinases (CARB) but differs in its apparent isoelectric point estimated as 6.3 and has been designated CARB-5 on this basis.

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Year:  1989        PMID： 2786828     DOI： 10.1111/j.1574-6968.1989.tb03080.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  9 in total

1.  Nucleotide sequence of the bla(RTG-2) (CARB-5) gene and phylogeny of a new group of carbenicillinases.

Authors:  D Choury; M F Szajnert; M L Joly-Guillou; K Azibi; M Delpech; G Paul
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

2.  Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype typhimurium DT104 from French patients.

Authors:  L Poirel; M Guibert; S Bellais; T Naas; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

Review 3.  A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors:  K Bush; G A Jacoby; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

4.  Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to beta-lactams.

Authors:  Hedi Mammeri; Laurent Poirel; Nicole Mangeney; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

5.  Characterization of the chromosomal cephalosporinases produced by Acinetobacter lwoffii and Acinetobacter baumannii clinical isolates.

Authors:  M Perilli; A Felici; A Oratore; G Cornaglia; G Bonfiglio; G M Rossolini; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

6.  Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii.

Authors:  Anaïs Potron; Laurent Poirel; Jacques Croizé; Vanessa Chanteperdrix; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2009-04-20       Impact factor: 5.191

7.  Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases.

Authors:  F Sanschagrin; N Bejaoui; R C Levesque
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

8.  Characterization and nucleotide sequence of CARB-6, a new carbenicillin-hydrolyzing beta-lactamase from Vibrio cholerae.

Authors:  D Choury; G Aubert; M F Szajnert; K Azibi; M Delpech; G Paul
Journal:  Antimicrob Agents Chemother       Date:  1999-02       Impact factor: 5.191

9.  Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.

Authors:  Laurent Poirel; Stéphane Corvec; Melina Rapoport; Pauline Mugnier; Alejandro Petroni; Fernando Pasteran; Diego Faccone; Marcelo Galas; Henri Drugeon; Vincent Cattoir; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2007-04-09       Impact factor: 5.191
  9 in total

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