Literature DB >> 2786784

Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium.

N Miyasaka1, K Sato, J Hashimoto, H Kohsaka, K Yamamoto, M Goto, K Inoue, T Matsuda, T Hirano, T Kishimoto.   

Abstract

Interleukin 6 (IL-6) production from synovial tissues of various diseases was examined. Augmented IL-6 production was found in inflammatory synovium not only in RA but also in other kinds of synovitis, including psoriatic arthritis and Behçet's disease. Increased amounts of IL-6-mRNA were detected in rheumatoid synovium using a dot blot hydridization technique. Furthermore, there was a positive correlation between IL-6 production and accumulation of plasma cells in the synovium. These findings suggest that IL-6 plays an important role not only in immune response but also in active inflammation in various kinds of synovitis.

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Year:  1989        PMID： 2786784     DOI： 10.1016/0090-1229(89)90175-x

Source DB:  PubMed          Journal:  Clin Immunol Immunopathol        ISSN： 0090-1229


  11 in total

1.  Aberrant cytokine production from tenosynovium in dialysis associated amyloidosis.

Authors:  N Miyasaka; K Sato; Y Kitano; M Higaki; K Nishioka; K Ohta
Journal:  Ann Rheum Dis       Date:  1992-06       Impact factor: 19.103

2.  Cytokine and nitric oxide production in the acute phase of bacterial cell wall-induced arthritis.

Authors:  J W Fuseler; E M Conner; J M Davis; R E Wolf; M B Grisham
Journal:  Inflammation       Date:  1997-02       Impact factor: 4.092

3.  4A11, a monoclonal antibody recognizing a novel antigen expressed on aberrant vascular endothelium. Upregulation in an in vivo model of contact dermatitis.

Authors:  A E Koch; B J Nickoloff; J Holgersson; B Seed; G K Haines; J C Burrows; S J Leibovich
Journal:  Am J Pathol       Date:  1994-02       Impact factor: 4.307

4.  Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice.

Authors:  L Yang; Y Ma; R Schoenfeld; M Griffiths; E Eichwald; B Araneo; J J Weis
Journal:  Infect Immun       Date:  1992-08       Impact factor: 3.441

Review 5.  Clinical studies in patients with Castleman's disease, Crohn's disease, and rheumatoid arthritis in Japan.

Authors:  Norihiro Nishimoto
Journal:  Clin Rev Allergy Immunol       Date:  2005-06       Impact factor: 8.667

6.  Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.

Authors:  T Nakajima; H Aono; T Hasunuma; K Yamamoto; I Maruyama; T Nosaka; M Hatanaka; K Nishioka
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

7.  Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab.

Authors:  Norihiro Nishimoto; Jun Hashimoto; Nobuyuki Miyasaka; Kazuhiko Yamamoto; Shinichi Kawai; Tsutomu Takeuchi; Norikazu Murata; Désirée van der Heijde; Tadamitsu Kishimoto
Journal:  Ann Rheum Dis       Date:  2007-05-07       Impact factor: 19.103

8.  Synovial tissue macrophages and joint erosion in rheumatoid arthritis.

Authors:  G Yanni; A Whelan; C Feighery; B Bresnihan
Journal:  Ann Rheum Dis       Date:  1994-01       Impact factor: 19.103

9.  Contrasting levels of in vitro cytokine production by rheumatoid synovial tissues demonstrating different patterns of mononuclear cell infiltration.

Authors:  G Yanni; A Whelan; C Feighery; W Quinlan; J Symons; G Duff; B Bresnihan
Journal:  Clin Exp Immunol       Date:  1993-09       Impact factor: 4.330

10.  Studies on early events of Borrelia burgdorferi-induced cytokine production in immunodeficient SCID mice by using a tissue chamber model for acute inflammation.

Authors:  U Hurtenbach; C Museteanu; J Gasser; U E Schaible; M M Simon
Journal:  Int J Exp Pathol       Date:  1995-04       Impact factor: 1.925
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