A-Nasser Munibari1, Ahmed Al-Motarreb1, Nora Al-Sagheer1, Hana Abu Hadi2, Ali Othman2, Nawar Al-Wather2, Abdu Hamoud3, Mutae Alawlagy4, Salem Almehdar5, Abdulkarim Alhammadi6, Mohammed Almogayed7, Giorgio Caretta8, Anees Al Jabri9, Luciano Agati10. 1. Medical Department, Faculty of Medicine and Health Sciences, Sanaa University, Yemen. 2. Medical Department, Al-Thawarah Hospital, Sanaa, Yemen. 3. Medical Department, Al-Jomhory Hospital, Sanaa, Yemen. 4. Cardiac Centre, Al-Dhalea, Yemen. 5. Medical Department, AL-Gomhorya Hospital, Aden, Yemen. 6. Medical Department, Al-Gomhory Hospital, Taiz, Yemen. 7. Medical Department, Yemen - German Hospital, Sanaa, Yemen. 8. Division of Cardiology, S. Andrea Hospital, ASL 5 Regione Liguria, La Spezia, Italy. Electronic address: giorgio.caretta@gmail.com. 9. Division of Cardiology, S. Andrea Hospital, ASL 5 Regione Liguria, La Spezia, Italy. 10. Department of Cardiology, Policlinico Umberto I, "La Sapienza" University of Rome, Italy.
Abstract
AIMS: There is a shortage of data about acute heart failure (AHF) in the young, including its underlying causes, clinical presentation and outcomes. We aim to describe clinical characteristics, causes and outcomes of AHF in Yemeni patients aged 50years or younger. METHODS AND RESULTS: we evaluated Yemeni patients with AHF enrolled in Gulf CARE registry. Patients were divided into two groups: young patients (≤50years) and older patients (>50years). A total of 1536 patients with AHF were enrolled, of whom 635 (41.3%) were 50years old or younger. The mean age for this group was 38.8 (±9.5) years; and 399 (62.8%) were males. Younger patients had a higher prevalence of non-ischemic cardiomyopathy (41% vs 11.1%, p<0.001), primary valvular disease (27.9% vs 3.2%, p<0.001), viral myocarditis (0.8% vs 0, p<0.001). Ischemic heart disease (61.6% vs 25.5%, p<0.001) and hypertensive heart disease (18.3% vs 6.3%, p<0.001) were more frequent in the elderly group. Cardiogenic shock was more frequent among younger patients (13.7% vs 7.0, p<0.001). In-hospital mortality was higher in patient aged ≤50years (12% vs 7.6%, p=0.002) while no difference in all-cause mortality was present at 3months (17.8 vs 14.5, p=0.089) and after 1year (21.9% vs 20.6%, p=0.56). CONCLUSION: This analysis of Gulf CARE registry represents the largest report of patients admitted with AHF in Yemen. There were differences among cause of HF and precipitating factors of AHF among younger and elderly patients. Younger patients had higher in-hospital mortality and more severe clinical condition at admission.
AIMS: There is a shortage of data about acute heart failure (AHF) in the young, including its underlying causes, clinical presentation and outcomes. We aim to describe clinical characteristics, causes and outcomes of AHF in Yemeni patients aged 50years or younger. METHODS AND RESULTS: we evaluated Yemeni patients with AHF enrolled in Gulf CARE registry. Patients were divided into two groups: young patients (≤50years) and older patients (>50years). A total of 1536 patients with AHF were enrolled, of whom 635 (41.3%) were 50years old or younger. The mean age for this group was 38.8 (±9.5) years; and 399 (62.8%) were males. Younger patients had a higher prevalence of non-ischemic cardiomyopathy (41% vs 11.1%, p<0.001), primary valvular disease (27.9% vs 3.2%, p<0.001), viral myocarditis (0.8% vs 0, p<0.001). Ischemic heart disease (61.6% vs 25.5%, p<0.001) and hypertensive heart disease (18.3% vs 6.3%, p<0.001) were more frequent in the elderly group. Cardiogenic shock was more frequent among younger patients (13.7% vs 7.0, p<0.001). In-hospital mortality was higher in patient aged ≤50years (12% vs 7.6%, p=0.002) while no difference in all-cause mortality was present at 3months (17.8 vs 14.5, p=0.089) and after 1year (21.9% vs 20.6%, p=0.56). CONCLUSION: This analysis of Gulf CARE registry represents the largest report of patients admitted with AHF in Yemen. There were differences among cause of HF and precipitating factors of AHF among younger and elderly patients. Younger patients had higher in-hospital mortality and more severe clinical condition at admission.
Authors: Mohammed M Al-Kebsi; Ahmed Al-Motarreb; Nawar Al-Wather; Amatasamad Al-Tanobi; Hisham A Al-Fakih; Abdulla Al-Dahbali; Luciano Agati Journal: Heart Views Date: 2022-02-11