Anna-Karin Wennstig1, Hans Garmo2, Per Hållström3, Petra Witt Nyström4, Per Edlund3, Carl Blomqvist5, Malin Sund6, Greger Nilsson7. 1. Department of Surgical and Perioperative Science, Surgery, Umeå University, Sweden; Department of Oncology, Sundsvall Hospital, Sweden. Electronic address: anakinwen@gmail.com. 2. King's College London, Faculty of Life Sciences and Medicine, UK; Regional Cancer Centre, Uppsala, Sweden. 3. Department of Oncology, Gävle Hospital, Sweden. 4. Department of Immunology, Uppsala University, Sweden. 5. Department of Oncology, Örebro University, Sweden. 6. Department of Surgical and Perioperative Science, Surgery, Umeå University, Sweden. 7. Department of Oncology, Gävle Hospital, Sweden; Department of Immunology, Uppsala University, Sweden; Department of Oncology, Visby Hospital, Sweden.
Abstract
PURPOSE: To determine the inter-observer variation in delineating the coronary arteries as organs at risk (OAR) in breast cancer (BC) radiotherapy (RT) and how this variation affects the estimated coronary artery radiation dose. METHOD: Delineation of the left main and the left anterior descending coronary artery (LMCA and LAD), and the right coronary artery (RCA), by using the heart atlas by Feng et al., was performed by three radiation oncologists in 32 women who had received adjuvant RT for BC. Centres of the arteries were calculated and distances between artery centres were measured and the artery radiation doses were estimated. The intraclass correlation coefficient (ICC) was used to quantify the variability in doses. RESULTS: Along the extent of RCA, the median distance between centres of arteries varied from 2 to 9mm with similar patterns over pairs of oncologists. For the LMCA-LAD the median distance varied from 1 to 4mm. The estimated maximum radiation doses showed an ICC variation from 0.82 to 0.97. CONCLUSION: The coronary arteries can be reliably identified and delineated as OARs in BC RT. The spatial variance is limited and the total variation in radiation dose is almost completely determined by the between patient variation.
PURPOSE: To determine the inter-observer variation in delineating the coronary arteries as organs at risk (OAR) in breast cancer (BC) radiotherapy (RT) and how this variation affects the estimated coronary artery radiation dose. METHOD: Delineation of the left main and the left anterior descending coronary artery (LMCA and LAD), and the right coronary artery (RCA), by using the heart atlas by Feng et al., was performed by three radiation oncologists in 32 women who had received adjuvant RT for BC. Centres of the arteries were calculated and distances between artery centres were measured and the artery radiation doses were estimated. The intraclass correlation coefficient (ICC) was used to quantify the variability in doses. RESULTS: Along the extent of RCA, the median distance between centres of arteries varied from 2 to 9mm with similar patterns over pairs of oncologists. For the LMCA-LAD the median distance varied from 1 to 4mm. The estimated maximum radiation doses showed an ICC variation from 0.82 to 0.97. CONCLUSION: The coronary arteries can be reliably identified and delineated as OARs in BC RT. The spatial variance is limited and the total variation in radiation dose is almost completely determined by the between patient variation.
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