Literature DB >> 27866815

N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat.

Narsimha Reddy Penthala1, Venumadhav Janganati1, Terri L Alpe2, Scott M Apana3, Marc S Berridge3, Peter A Crooks4, Michael J Borrelli5.   

Abstract

The aim of this study was to determine the uptake of intravenously administered N-[11CH3]-dimethylaminoparthenolide (DMAPT) into orthotopic 9LSF glioblastoma brain tumors in Fisher 344 rats from positron emission tomography (PET) imaging studies. [11C]methyl iodide (11CH3I) was utilized as a [11C]-labeling reagent to label the precursor methylaminoparthenolide (MAPT) intermediate. From PET imaging studies it was found that brain uptake of N-[11CH3]DMAPT into brain tumor tissue was rapid (30min), and considerably higher than that in the normal brain tissue. Copyright Â
© 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Dimethylaminoparthenolide (DMAPT); PET-imaging; Uptake into brain; [(11)C]-labeled DMAPT

Mesh：

Substances：

Year:  2016        PMID： 27866815      PMCID： PMC5154296          DOI： 10.1016/j.bmcl.2016.11.015

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  34 in total

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Authors:  A D'Anneo; D Carlisi; M Lauricella; R Puleio; R Martinez; S Di Bella; P Di Marco; S Emanuele; R Di Fiore; A Guercio; R Vento; G Tesoriere
Journal:  Cell Death Dis       Date:  2013-10-31       Impact factor: 8.469

10.  High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe.

Authors:  Ruimin Huang; Stefan Harmsen; Jason M Samii; Hazem Karabeber; Kenneth L Pitter; Eric C Holland; Moritz F Kircher
Journal:  Theranostics       Date:  2016-05-07       Impact factor: 11.556
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Journal:  Medchemcomm       Date:  2019-08-01       Impact factor: 3.597
  1 in total

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