Dara Kraitchman1, Ihab Kamel1, Clifford Weiss2, Christos Georgiades3. 1. Departments of Radiology, Interventional Radiology Center, Sheikh Zayed Tower, Suite 7203, 1800 Orleans Street, Baltimore, MD 21287. 2. Departments of Radiology, Interventional Radiology Center, Sheikh Zayed Tower, Suite 7203, 1800 Orleans Street, Baltimore, MD 21287; Surgery, Johns Hopkins University, Interventional Radiology Center, Sheikh Zayed Tower, Suite 7203, 1800 Orleans Street, Baltimore, MD 21287. 3. Departments of Radiology, Interventional Radiology Center, Sheikh Zayed Tower, Suite 7203, 1800 Orleans Street, Baltimore, MD 21287; Surgery, Johns Hopkins University, Interventional Radiology Center, Sheikh Zayed Tower, Suite 7203, 1800 Orleans Street, Baltimore, MD 21287. Electronic address: g_christos@hotmail.com.
Abstract
PURPOSE: To define percutaneously accessible, anatomically reproducible swine lymph nodes using magnetic resonance imaging, ultrasound, and ethiodized oil (Lipiodol; Guerbet, Bloomington, Indiana) lymphangiography. MATERIALS AND METHODS: Five adult female swine (Yorkshire, 50-60 kg) were used. Under general anesthesia, T1-weighted and T2-weighted, coronal and axial images of the entire swine were obtained. The animal's extrathoracic, extraperitoneal soft tissues from the neck to the groins were examined with ultrasound. Lymph nodes ≥ 1 cm were marked before the animal was transferred to the angiography suite. Under ultrasound guidance, the nodes were accessed, and lymphangiograms were obtained. The imaging findings between the 3 modalities were correlated, and the lymph node drainage was mapped. RESULTS: Four lymph nodes/lymph node groups were identified that were reproducible in all 5 animals, > 1 cm and percutaneously accessible: submandibular node, superficial cervical lymph node group, subiliac node, and superficial inguinal lymph node group. Drainage of these nodes mirrored human anatomy. The abdominopelvic lymphatics formed a retroperitoneal cisterna chyli and drained cephalad via a thoracic duct. CONCLUSIONS: The swine exhibits reproducible lymphatic anatomy with at least 4 percutaneously accessible lymph nodes/lymph node groups. Based on these results, the swine may be a suitable large animal model for research into lymphatic interventions.
PURPOSE: To define percutaneously accessible, anatomically reproducible swine lymph nodes using magnetic resonance imaging, ultrasound, and ethiodized oil (Lipiodol; Guerbet, Bloomington, Indiana) lymphangiography. MATERIALS AND METHODS: Five adult female swine (Yorkshire, 50-60 kg) were used. Under general anesthesia, T1-weighted and T2-weighted, coronal and axial images of the entire swine were obtained. The animal's extrathoracic, extraperitoneal soft tissues from the neck to the groins were examined with ultrasound. Lymph nodes ≥ 1 cm were marked before the animal was transferred to the angiography suite. Under ultrasound guidance, the nodes were accessed, and lymphangiograms were obtained. The imaging findings between the 3 modalities were correlated, and the lymph node drainage was mapped. RESULTS: Four lymph nodes/lymph node groups were identified that were reproducible in all 5 animals, > 1 cm and percutaneously accessible: submandibular node, superficial cervical lymph node group, subiliac node, and superficial inguinal lymph node group. Drainage of these nodes mirrored human anatomy. The abdominopelvic lymphatics formed a retroperitoneal cisterna chyli and drained cephalad via a thoracic duct. CONCLUSIONS: The swine exhibits reproducible lymphatic anatomy with at least 4 percutaneously accessible lymph nodes/lymph node groups. Based on these results, the swine may be a suitable large animal model for research into lymphatic interventions.
Authors: Sang Wha Kim; Adams Hei Long Yuen; Cherry Tsz Ching Poon; Joon Oh Hwang; Chang Jun Lee; Moon-Kwan Oh; Ki Tae Kim; Hyoun Joong Kim; Sib Sankar Giri; Sang Guen Kim; Jun Kwon; Sung Bin Lee; Min Cheol Choi; Se Chang Park Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379