Tongtong Yu1, Yuanyuan Dong1, Zhijun Sun1, Zhaoqing Sun2. 1. Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China. 2. Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China. Electronic address: sunzhaoqing@vip.163.com.
Abstract
BACKGROUND: Mean platelet volume to platelet count ratio (MPV/P ratio) has been demonstrated to be a predictor of adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We aimed to assess whether MPV/P ratio is a useful marker to predict long-term prognosis in NSTEMI patients undergoing PCI. Moreover, the prognostic accuracy of MPV/P ratio was compared with MPV and GRACE score. METHODS: In a retrospective cohort study, according to the baseline MPV/P values, 887 consecutive NSTEMI patients undergoing PCI were divided into two groups: the high MPV/P group (n=296, MPV/P ≥0.054) and the low MPV/P group (n=591, MPV/P<0.054). Clinical endpoints were all-cause mortality and all-cause mortality/nonfatal reinfarction. RESULTS: Multivariate analysis showed that high MPV/P was an independent predictor of all-cause mortality [HRs: 1.973, 95% CI: 1.528-2.549, P<0.001], and all-cause mortality/nonfatal myocardial reinfarction [HRs: 1.289, 95% CI: 1.181-1.408, P<0.001]. MPV/P ratio has good accuracy for predicting clinical endpoints. The discriminatory performance of MPV/P ratio was similar to GRACE score but better than MPV (for all-cause mortality: MPV/P vs. GRACE: z=0.205, p=0.837; MPV/P vs. MPV: z=2.677, p=0.008; GRACE vs. MPV: z=3.017, p=0.003; for all-cause mortality/nonfatal myocardial: MPV/P vs. GRACE: z=1.098, p=0.272; MPV/P vs. MPV: z=4.026, p<0.001; GRACE vs. MPV: z=4.962, p<0.001). CONCLUSIONS: MPV/P ratio was similar to GRACE score but better than MPV for predicting all-cause mortality and all-cause mortality/nonfatal myocardial reinfarction in NSTEMI patients undergoing PCI. However, MPV/P ratio is easier to calculate than GRACE score.
BACKGROUND: Mean platelet volume to platelet count ratio (MPV/P ratio) has been demonstrated to be a predictor of adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We aimed to assess whether MPV/P ratio is a useful marker to predict long-term prognosis in NSTEMI patients undergoing PCI. Moreover, the prognostic accuracy of MPV/P ratio was compared with MPV and GRACE score. METHODS: In a retrospective cohort study, according to the baseline MPV/P values, 887 consecutive NSTEMI patients undergoing PCI were divided into two groups: the high MPV/P group (n=296, MPV/P ≥0.054) and the low MPV/P group (n=591, MPV/P<0.054). Clinical endpoints were all-cause mortality and all-cause mortality/nonfatal reinfarction. RESULTS: Multivariate analysis showed that high MPV/P was an independent predictor of all-cause mortality [HRs: 1.973, 95% CI: 1.528-2.549, P<0.001], and all-cause mortality/nonfatal myocardial reinfarction [HRs: 1.289, 95% CI: 1.181-1.408, P<0.001]. MPV/P ratio has good accuracy for predicting clinical endpoints. The discriminatory performance of MPV/P ratio was similar to GRACE score but better than MPV (for all-cause mortality: MPV/P vs. GRACE: z=0.205, p=0.837; MPV/P vs. MPV: z=2.677, p=0.008; GRACE vs. MPV: z=3.017, p=0.003; for all-cause mortality/nonfatal myocardial: MPV/P vs. GRACE: z=1.098, p=0.272; MPV/P vs. MPV: z=4.026, p<0.001; GRACE vs. MPV: z=4.962, p<0.001). CONCLUSIONS: MPV/P ratio was similar to GRACE score but better than MPV for predicting all-cause mortality and all-cause mortality/nonfatal myocardial reinfarction in NSTEMI patients undergoing PCI. However, MPV/P ratio is easier to calculate than GRACE score.
Authors: Tomasz K Urbanowicz; Michał Michalak; Weronika Mikołajewska; Michał Rodzki; Bartłomiej Perek; Anna Olasińska-Wiśniewska; Michał Bociański; Marek Jemielity Journal: Kardiochir Torakochirurgia Pol Date: 2022-01-09