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Literature DB >> 2786596

The serum interleukin 6 response to elective surgery.

A Shenkin¹, W D Fraser, J Series, F P Winstanley, A C McCartney, H J Burns, J Van Damme.

Abstract

We have investigated changes in serum interleukin 6 (IL-6) in patients undergoing elective cholecystectomy. Serum IL-6 increased in all patients within 1.5 hour of incision, reaching a maximum between 1.5-4 hours after incision (median 50 U/ml; range 22-79 U/ml). The maximum serum IL-6 correlated with the length of the operation (r = 0.95). Serum C-reactive protein was not detectable until 8-12 hours post-incision, but maximum serum C-reactive protein did not correlate with maximum serum IL-6 concentration or length of operation. There was no consistent increase in plasma interleukin 1 or tumour necrosis factor following surgery. Serum IL-6 is an early marker of tissue damage and may be of value in the study of the metabolic response to injury.

Entities: Disease Gene Species

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Year: 1989 PMID： 2786596

Source DB: PubMed Journal: Lymphokine Res ISSN： 0277-6766

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Cited

46 in total

1. Change in mitochondrial membrane potential in peripheral blood lymphocytes, especially in natural killer cells, is a possible marker for surgical stress on the immune system.

Authors: Arimichi Takabayashi; Michiyuki Kanai; Yasuhiro Kawai; Shingo Iwata; Tetsuro Sasada; Kazutaka Obama; Yoshiro Taki
Journal: World J Surg Date: 2003-05-13 Impact factor: 3.352

2. Selective and early increase of IL-1 inhibitors, IL-6 and cortisol after elective surgery.

Authors: F Di Padova; C Pozzi; M J Tondre; R Tritapepe
Journal: Clin Exp Immunol Date: 1991-07 Impact factor: 4.330

3. Acute release of cytokines is proportional to tissue injury induced by surgical trauma and shock in rats.

Authors: H Bitterman; A Kinarty; H Lazarovich; N Lahat
Journal: J Clin Immunol Date: 1991-07 Impact factor: 8.317

4. Perioperative measurements of IL-6 and α-melanocyte stimulating hormone in a cardiac transplant patient after ventricular assist device support.

Authors: T Sakai; A Kudoh; N Kotani; T W Latson; A H Giesecke; A Matsuki
Journal: J Anesth Date: 1995-03 Impact factor: 2.078

Review 10. Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation.

Authors: Chikao Miki; Masato Kusunoki; Yasuhiro Inoue; Keiichi Uchida; Yasuhiko Mohri; John A C Buckels; Paul McMaster
Journal: Surg Today Date: 2008-09-27 Impact factor: 2.549

The serum interleukin 6 response to elective surgery.

1. Change in mitochondrial membrane potential in peripheral blood lymphocytes, especially in natural killer cells, is a possible marker for surgical stress on the immune system.

2. Selective and early increase of IL-1 inhibitors, IL-6 and cortisol after elective surgery.

3. Acute release of cytokines is proportional to tissue injury induced by surgical trauma and shock in rats.

4. Perioperative measurements of IL-6 and α-melanocyte stimulating hormone in a cardiac transplant patient after ventricular assist device support.

5. New approaches to sepsis: molecular diagnostics and biomarkers.

6. Response of serum cytokines in patients undergoing laparoscopic cholecystectomy.

7. IL-6 and TNF alpha release in association with neutrophil activation after cardiopulmonary bypass surgery.

8. Interleukin-6 and coagulation-fibrinolysis fluctuations after laparoscopic and conventional cholecystectomy.

9. Effects of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) on neutrophil elastase release.

Review 10. Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation.