Literature DB >> 27865951

Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats.

Xinpeng Li1, Jing Wang2, Hong Zhang2, Quanbin Zhang3.   

Abstract

We investigated the renal protective effect of low-molecular-weight sulfated polysaccharide (LMWSP) fractions extracted from Laminaria japonica on glycerol-induced acute kidney injury (AKI) in rats. Glycerol treatment significantly increased serum creatinine (SCr) and blood urea nitrogen (BUN) levels. Intraperitoneal injection of LMWSP fractions markedly decreased SCr and BUN levels and reduced renal swelling. The fraction of 1.0M NaCl displayed the best renal protective effect of all fractions in attenuating AKI and maintaining blood glucose.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Acute kidney injury; Low-molecular-weight sulfated polysaccharide; Renal protective effect

Mesh：

Substances：

Year:  2016        PMID： 27865951     DOI： 10.1016/j.ijbiomac.2016.11.051

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  8 in total

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