Literature DB >> 27865878

Bone marrow mesenchymal stem cells decrease CHOP expression and neuronal apoptosis after spinal cord injury.

Chuanlong Gu1, Heyangzi Li1, Chao Wang1, Xinghui Song2, Yuemin Ding3, Mingzhi Zheng4, Wei Liu5, Yingying Chen1, Xiaoming Zhang1, Linlin Wang6.   

Abstract

Spinal cord injury (SCI) leads to irreversible neuronal loss and ultimately leads to paralysis. Bone marrow derived mesenchymal stem cells (BMSCs) have been demonstrated to be an effective approach to treat SCI. The present study was designed to investigate the role of BMSCs in rats with spinal cord injury and in oxygen-glucose deprivation (OGD) treated motor neurons. The results demonstrated that BMSCs could improve locomotor function and decrease expression of pro-apoptotic transcription factor C/EBP homologous protein (CHOP) and apoptosis after SCI. Furthermore, co-culture with BMSCs or conditioned medium from BMSCs could also decrease the expression of CHOP and apoptosis in post-OGD motor neurons, supporting that BMSCs exerts protective effects by decreasing the expression of CHOP in injured motor neurons. Our findings provide a potential novel mechanism for BMSCs treatments in patients with SCI. Copyright Â
© 2016. Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  Apoptosis; Bone marrow mesenchymal stem cells; C/EBP homology protein; Endoplasmic reticulum stress; Spinal cord injury

Mesh：

Substances：

Year:  2016        PMID： 27865878     DOI： 10.1016/j.neulet.2016.11.032

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

Review 1.  Progress in Stem Cell Therapy for Spinal Cord Injury.

Authors:  Liansheng Gao; Yucong Peng; Weilin Xu; Pingyou He; Tao Li; Xiaoyang Lu; Gao Chen
Journal:  Stem Cells Int       Date:  2020-11-05       Impact factor: 5.443

2.  CD157 in bone marrow mesenchymal stem cells mediates mitochondrial production and transfer to improve neuronal apoptosis and functional recovery after spinal cord injury.

Authors:  Jing Li; Heyangzi Li; Simin Cai; Shi Bai; Huabo Cai; Xiaoming Zhang
Journal:  Stem Cell Res Ther       Date:  2021-05-17       Impact factor: 6.832

3.  Thrombospondin-1 modified bone marrow mesenchymal stem cells (BMSCs) promote neurite outgrowth and functional recovery in rats with spinal cord injury.

Authors:  Yujie Pu; Ke Meng; Chuanlong Gu; Linlin Wang; Xiaoming Zhang
Journal:  Oncotarget       Date:  2017-10-24

4.  The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model.

Authors:  Donghe Han; Shurui Chen; Shiqiang Fang; Shiqiong Liu; Meihua Jin; Zhanpeng Guo; Yajiang Yuan; Yansong Wang; Chang Liu; Xifan Mei
Journal:  Biomed Res Int       Date:  2017-07-05       Impact factor: 3.411

Review 5.  Roles of Mesenchymal Stem Cells in Spinal Cord Injury.

Authors:  Jing Qu; Huanxiang Zhang
Journal:  Stem Cells Int       Date:  2017-05-28       Impact factor: 5.443

6.  Mitochondrial Transfer from Bone Marrow Mesenchymal Stem Cells to Motor Neurons in Spinal Cord Injury Rats via Gap Junction.

Authors:  Heyangzi Li; Chao Wang; Teng He; Tengfei Zhao; Ying-Ying Chen; Yue-Liang Shen; Xiaoming Zhang; Lin-Lin Wang
Journal:  Theranostics       Date:  2019-03-17       Impact factor: 11.556

7.  Developing Novel Therapies for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 7]: Opportunities From Restorative Neurobiology.

Authors:  Aref-Ali Gharooni; Brian K Kwon; Michael G Fehlings; Timothy F Boerger; Ricardo Rodrigues-Pinto; Paul Aarne Koljonen; Shekar N Kurpad; James S Harrop; Bizhan Aarabi; Vafa Rahimi-Movaghar; Jefferson R Wilson; Benjamin M Davies; Mark R N Kotter; James D Guest
Journal:  Global Spine J       Date:  2022-02

8.  Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress.

Authors:  Sei-Ichiro Motegi; Akiko Sekiguchi; Akihiko Uchiyama; Akihito Uehara; Chisako Fujiwara; Sahori Yamazaki; Buddhini Perera; Hideharu Nakamura; Sachiko Ogino; Yoko Yokoyama; Ryoko Akai; Takao Iwawaki; Osamu Ishikawa
Journal:  Sci Rep       Date:  2017-12-07       Impact factor: 4.379

9.  Human Brain-Derived Neurotrophic Factor Gene-Modified Bone Marrow Mesenchymal Stem Cells Combined With Erythropoietin Can Improve Acute Spinal Cord Injury.

Authors:  YongLei Li; Hongchen Wang; Xiaofang Ding; Jiancheng Shen; Haitao Zhou; Dengxue Jiang; Chen Jin; Kuang Li
Journal:  Dose Response       Date:  2020-03-30       Impact factor: 2.658
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.