| Literature DB >> 27865848 |
Xiaofang Cui1, Suying Dang2, Yan Wang3, Yan Chen4, Jia Zhou4, Chunling Shen2, Ying Kuang5, Jian Fei5, Lungen Lu3, Zhugang Wang6.
Abstract
Retinol dehydrogenase 13 (RDH13) is a mitochondrion-localized member of the short-chain dehydrogenases/reductases (SDRs) superfamily that participates in metabolism of some compounds. Rdh13 mRNA is most highly expressed in mouse liver. Rdh13 deficiency reduces the extent of liver injury and fibrosis, reduces hepatic stellate cell (HSC) activation, attenuates collagen I (II), tissue inhibitor of metalloproteinase 1 (TIMP-1) and transforming growth factor beta 1 (Tgf-β1) expression. The results indicate an important role of Rdh13 and suggest RDH13 as a possible new therapeutic target for CCl4-induced fibrosis.Entities:
Keywords: Carbon tetrachloride; Hepatic stellate cells; Knockout; Liver fibrosis; Retinol dehydrogenase 13
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Year: 2016 PMID： 27865848 DOI： 10.1016/j.toxlet.2016.11.010
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372