Sanjeewa Kularatna1, Joshua Byrnes2, Yih Kai Chan3, Melinda J Carrington3, Simon Stewart3, Paul A Scuffham4. 1. Centre for Applied Health Economics, School of Medicine, Griffith University, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Queensland, Australia; Centre for Research Excellence to Reduce Inequality in Heart Disease, Australia. Electronic address: s.kularatna@griffith.edu.au. 2. Centre for Applied Health Economics, School of Medicine, Griffith University, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Queensland, Australia; Centre for Research Excellence to Reduce Inequality in Heart Disease, Australia. 3. Centre for Research Excellence to Reduce Inequality in Heart Disease, Australia; Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, Australia. 4. Centre for Applied Health Economics, School of Medicine, Griffith University, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Queensland, Australia.
Abstract
BACKGROUND: The EQ-5D-3L, a generic multi-attribute utility instrument (MAUI), is widely employed to assist in economic evaluations in health care. The EQ-5D-3L lacks sensitivity when used in conditions such as cardiovascular disease (CVD). Although there are number of CVD specific quality of life instruments, currently, there are no CVD specific MAUIs. The aim of this study is to investigate the discriminative ability and responsiveness of the EQ-5D-3L and the Minnesota Living with Heart Failure Questionnaire (MLHF), a CVD specific quality of life instrument in a group of heart failure patients. METHODS: The psychometric performance of the EQ-5D-3L and the MLHF was assessed using data from a randomised trial for a heart failure management intervention. The two instruments were compared for discrimination, responsiveness and agreement. The severity groups were defined using New York Heart Association functional classes. RESULTS: The effect sizes for severe classes were generally similar showing good discrimination. The MLHF recorded better responsiveness between the time points than the EQ-5D-3L which was indicated by higher effect sizes and standardised response means. The change in MLHF summary scores between the time points was significant (p<0.005; paired t-test). The overall agreement between the two measures was low. CONCLUSION: The low correlation indicates that the two classification systems cover different aspects of health space. Comparison of CVD specific instruments with other generic MAUIs such as EQ-5D-3L and AQOL-8D is recommended for further research.
RCT Entities:
BACKGROUND: The EQ-5D-3L, a generic multi-attribute utility instrument (MAUI), is widely employed to assist in economic evaluations in health care. The EQ-5D-3L lacks sensitivity when used in conditions such as cardiovascular disease (CVD). Although there are number of CVD specific quality of life instruments, currently, there are no CVD specific MAUIs. The aim of this study is to investigate the discriminative ability and responsiveness of the EQ-5D-3L and the Minnesota Living with Heart Failure Questionnaire (MLHF), a CVD specific quality of life instrument in a group of heart failurepatients. METHODS: The psychometric performance of the EQ-5D-3L and the MLHF was assessed using data from a randomised trial for a heart failure management intervention. The two instruments were compared for discrimination, responsiveness and agreement. The severity groups were defined using New York Heart Association functional classes. RESULTS: The effect sizes for severe classes were generally similar showing good discrimination. The MLHF recorded better responsiveness between the time points than the EQ-5D-3L which was indicated by higher effect sizes and standardised response means. The change in MLHF summary scores between the time points was significant (p<0.005; paired t-test). The overall agreement between the two measures was low. CONCLUSION: The low correlation indicates that the two classification systems cover different aspects of health space. Comparison of CVD specific instruments with other generic MAUIs such as EQ-5D-3L and AQOL-8D is recommended for further research.
Authors: Sanjeewa Kularatna; Donna Rowen; Clara Mukuria; Steven McPhail; Gang Chen; Brendan Mulhern; Jennifer A Whitty; Joshua Byrnes; Paul Scuffham; John Atherton; Stefan Höfer; William Parsonage Journal: Qual Life Res Date: 2021-05-26 Impact factor: 4.147
Authors: Gian Luca Di Tanna; Michael Urbich; Heidi S Wirtz; Barbara Potrata; Marieke Heisen; Craig Bennison; John Brazier; Gary Globe Journal: Pharmacoeconomics Date: 2020-11-30 Impact factor: 4.981
Authors: Hasnain M Dalal; Rod S Taylor; Kate Jolly; Russell C Davis; Patrick Doherty; Jackie Miles; Robin van Lingen; Fiona C Warren; Colin Green; Jennifer Wingham; Colin Greaves; Susannah Sadler; Melvyn Hillsdon; Charles Abraham; Nicky Britten; Julia Frost; Sally Singh; Christopher Hayward; Victoria Eyre; Kevin Paul; Chim C Lang; Karen Smith Journal: Eur J Prev Cardiol Date: 2018-10-10 Impact factor: 7.804