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Literature DB >> 27864649

Cardioprotective effects of omega 3 fatty acids: origin of the variability.

Abstract

Since 40 years, it is known that omega-3 poly-unsaturated fatty acids (ω3 PUFAs) have cardioprotective effects. These include antiarrhythmic effects, improvements of autonomic function, endothelial function, platelet anti-aggregation and inflammatory properties, lowering blood pressure, plaque stabilization and reduced atherosclerosis. However, recently, conflicting results regarding the health benefits of ω3 PUFAs from seafood or ω3 PUFAs supplements have emerged. The aim of this review is to examine recent literature regarding health aspects of ω3 PUFAs intake from fish or supplements, and to discuss different arguments/reasons supporting these conflicting findings.

Entities: Chemical Disease

Keywords: Cardiac arrhythmias; Controversies; Sarcomere proteins; ω-3 PUFA

Mesh：

Substances：
Fatty Acids, Omega-3

Year: 2016 PMID： 27864649 DOI： 10.1007/s10974-016-9459-z

Source DB: PubMed Journal: J Muscle Res Cell Motil ISSN： 0142-4319 Impact factor: 2.698

75 in total

Review 1. n-3 fatty acids in cardiovascular disease.

Authors: Raffaele De Caterina
Journal: N Engl J Med Date: 2011-06-23 Impact factor: 91.245

2. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia.

Authors: P N Durrington; D Bhatnagar; M I Mackness; J Morgan; K Julier; M A Khan; M France
Journal: Heart Date: 2001-05 Impact factor: 5.994

3. Effects of dietary n-3 fatty acids on contractility, Na+ and K+ currents in a rat cardiomyocyte model of arrhythmia.

Authors: W R Leifert; A Jahangiri; D A Saint; E J McMurchie
Journal: J Nutr Biochem Date: 2000 Jul-Aug Impact factor: 6.048

4. What role for membranes in determining the higher sodium pump molecular activity of mammals compared to ectotherms?

Authors: P L Else; B J Wu
Journal: J Comp Physiol B Date: 1999-07 Impact factor: 2.200

Review 5. Cardioprotection by hormetic responses to aldehyde.

Authors: Motoaki Sano
Journal: Circ J Date: 2010-08-12 Impact factor: 2.993

6. Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.

Authors: Gavin K Doolan; Rekha G Panchal; Eva L Fonnes; Alison L Clarke; David A Williams; Steven Petrou
Journal: FASEB J Date: 2002-08-21 Impact factor: 5.191

7. The calcium uptake of the rat heart sarcoplasmic reticulum is altered by dietary lipid.

Authors: G E Taffet; T T Pham; D L Bick; M L Entman; H J Pownall; R J Bick
Journal: J Membr Biol Date: 1993-01 Impact factor: 1.843

8. Membrane lipids and sodium pumps of cattle and crocodiles: an experimental test of the membrane pacemaker theory of metabolism.

Authors: B J Wu; A J Hulbert; L H Storlien; P L Else
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2004-09 Impact factor: 3.619

9. Stressing the heart of the matter: re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids.

Authors: Ethan J Anderson; David A Taylor
Journal: F1000 Med Rep Date: 2012-07-02

Review 3. Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress.

Authors: Katarina Andelova; Barbara Szeiffova Bacova; Matus Sykora; Peter Hlivak; Miroslav Barancik; Narcis Tribulova
Journal: Int J Mol Sci Date: 2022-01-26 Impact factor: 5.923

3 in total