Literature DB >> 27864143

C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer.

Chang Liu1, Yang Yu2, Guangliang Yin3, Junxia Zhang1, Wei Wen1, Xianhui Ruan2, Dapeng Li2, Shuang Zhang4, Wenjun Cai3, Ming Gao5, Lingyi Chen6.   

Abstract

The genetic causes for familial nonmedullary thyroid cancer (FNMTC) remain largely unknown. Through genetic linkage analysis and exome sequencing, C14orf93 (RTFC), PYGL, and BMP4 were identified as susceptibility gene candidates in a FNMTC family. By examining the expression and the oncogenic functions of these candidate genes, PYGL and BMP4 were excluded. We further characterized the functions of the uncharacterized gene RTFC in thyroid cancer. RTFC promotes thyroid cancer cell survival under starving conditions, and thyroid cancer cell migration. The R115Q, V205M and G209D RTFC mutants enhance the colony forming capacity of thyroid cancer cells, and are able to transform normal thyroid cells. In summary, our data suggest the roles of RTFC in thyroid carcinogenesis.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  C14orf93; Exome sequencing; RTFC; Thyroid cancer

Mesh：

Substances：

Year:  2016        PMID： 27864143     DOI： 10.1016/j.bbrc.2016.11.078

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

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Review 2.  A Systematic Literature Review of Whole Exome and Genome Sequencing Population Studies of Genetic Susceptibility to Cancer.

Authors:  Alisa M Goldstein; Elizabeth M Gillanders; Melissa Rotunno; Rolando Barajas; Mindy Clyne; Elise Hoover; Naoko I Simonds; Tram Kim Lam; Leah E Mechanic
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2020-05-28       Impact factor: 4.254

3.  Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.

Authors:  Yang Yu; Chang Liu; Junxia Zhang; Mimi Zhang; Wei Wen; Xianhui Ruan; Dapeng Li; Shuang Zhang; Ming Gao; Lingyi Chen
Journal:  Sci Rep       Date:  2017-02-23       Impact factor: 4.379

Review 4.  Susceptibility Genes and Chromosomal Regions Associated With Non-Syndromic Familial Non-Medullary Thyroid Carcinoma: Some Pathogenetic and Diagnostic Keys.

Authors:  María Sánchez-Ares; Soledad Cameselle-García; Ihab Abdulkader-Nallib; Gemma Rodríguez-Carnero; Carolina Beiras-Sarasquete; José Antonio Puñal-Rodríguez; José Manuel Cameselle-Teijeiro
Journal:  Front Endocrinol (Lausanne)       Date:  2022-02-28       Impact factor: 5.555

5.  Identification of NID1 as a novel candidate susceptibility gene for familial non-medullary thyroid carcinoma using whole-exome sequencing.

Authors:  Luis Eduardo Barbalho de Mello; Thaise Nayane Ribeiro Carneiro; Aline Neves Araujo; Camila Xavier Alves; Pedro Alexandre Favoretto Galante; Vanessa Candiotti Buzatto; Maria das Graças de Almeida; Karina Marques Vermeulen-Serpa; Sancha Helena de Lima Vale; Fernando José de Pinto Paiva; José Brandão-Neto; Janete Maria Cerutti
Journal:  Endocr Connect       Date:  2022-01-31       Impact factor: 3.335
  5 in total

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