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Literature DB >> 2786334

Human pregnancy-specific beta 1-glycoproteins are coded within chromosome 19.

T R Barnett¹, W Pickle, P M Rae, J Hart, M Kamarck, J Elting.

Abstract

We have isolated and characterized cDNAs that code for apoproteins having amino acid sequences highly similar to pregnancy-specific beta 1-glycoproteins (PS beta G). cDNAs coding for PS beta Gs, as well as the cDNA clone reported here, are members of the carcinoembryonic antigen (CEA) gene family. The previous localization of CEA-related genes to human chromosome 19, and the high level of DNA sequence conservation in the CEA family, suggested that the PS beta G genes are also located on this chromosome. We demonstrate here that chromosome 19 is indeed the site of PS beta G sequences. Our finding is in contrast to the recently reported indication that pregnancy-specific glycoproteins are encoded in chromosomes X and 6.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2786334 PMCID： PMC1715672

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

14 in total

1. Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors.

Authors: W Zimmermann; B Weber; B Ortlieb; F Rudert; W Schempp; H H Fiebig; J E Shively; S von Kleist; J A Thompson
Journal: Cancer Res Date: 1988-05-01 Impact factor: 12.701

2. Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family.

Authors: R J Paxton; G Mooser; H Pande; T D Lee; J E Shively
Journal: Proc Natl Acad Sci U S A Date: 1987-02 Impact factor: 11.205

3. Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11.

Authors: M E Kamarck; J J Elting; J T Hart; S J Goebel; P M Rae; M A Nothdurft; J J Nedwin; T R Barnett
Journal: Proc Natl Acad Sci U S A Date: 1987-08 Impact factor: 11.205

4. Chromosome mapping of cell membrane antigens expressed on activated B cells.

Authors: F E Katz; M Parkar; K Stanley; L J Murray; E A Clark; M F Greaves
Journal: Eur J Immunol Date: 1985-01 Impact factor: 5.532

Review 5. CEA-related antigens: molecular biology and clinical significance.

Authors: J E Shively; J D Beatty
Journal: Crit Rev Oncol Hematol Date: 1985 Impact factor: 6.312

6. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

7. Chromosomal assignment of a family of human oncogenes.

Authors: J Ryan; P E Barker; K Shimizu; M Wigler; F H Ruddle
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

8. Human pregnancy-specific beta 1-glycoprotein: a new member of the carcinoembryonic antigen gene family.

Authors: S Watanabe; J Y Chou
Journal: Biochem Biophys Res Commun Date: 1988-04-29 Impact factor: 3.575

9. Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen.

Authors: M Neumaier; W Zimmermann; L Shively; Y Hinoda; A D Riggs; J E Shively
Journal: J Biol Chem Date: 1988-03-05 Impact factor: 5.157

10. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.

Authors: P GOLD; S O FREEDMAN
Journal: J Exp Med Date: 1965-03-01 Impact factor: 14.307

3 in total