Literature DB >> 27862818

Tetrazine-Responsive Self-immolative Linkers.

Kevin Neumann1, Sarthak Jain1, Alessia Gambardella1, Sarah E Walker1, Elsa Valero1, Annamaria Lilienkampf1, Mark Bradley1.   

Abstract

Molecules that undergo activation or modulation following the addition of benign external small-molecule chemical stimuli have numerous applications. Here, we report the highly efficient "decaging" of a variety of moieties by activation of a "self-immolative" linker, by application of water-soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Diels-Alder reaction; doxorubicin; nanoparticles; prodrugs; tetrazine

Mesh：

Substances：

Year:  2016        PMID： 27862818     DOI： 10.1002/cbic.201600560

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  8 in total

1.  Bioorthogonal chemistry.

Authors:  Samuel L Scinto; Didier A Bilodeau; Robert Hincapie; Wankyu Lee; Sean S Nguyen; Minghao Xu; Christopher W Am Ende; M G Finn; Kathrin Lang; Qing Lin; John Paul Pezacki; Jennifer A Prescher; Marc S Robillard; Joseph M Fox
Journal:  Nat Rev Methods Primers       Date:  2021-04-15

Review 2.  The Future of Bioorthogonal Chemistry.

Authors:  Neal K Devaraj
Journal:  ACS Cent Sci       Date:  2018-07-23       Impact factor: 14.553

3.  A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation.

Authors:  Ha Phuong Nguyen; Sabrina Stewart; Mikiembo N Kukwikila; Sioned Fôn Jones; Daniel Offenbartl-Stiegert; Shiqing Mao; Shankar Balasubramanian; Stephan Beck; Stefan Howorka
Journal:  Angew Chem Int Ed Engl       Date:  2019-04-12       Impact factor: 15.336

Review 4.  Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs.

Authors:  Yayue Wang; Chang Zhang; Haoxing Wu; Ping Feng
Journal:  Molecules       Date:  2020-11-30       Impact factor: 4.411

5.  Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor.

Authors:  Mark A R de Geus; G J Mirjam Groenewold; Elmer Maurits; Can Araman; Sander I van Kasteren
Journal:  Chem Sci       Date:  2020-09-08       Impact factor: 9.825

6.  Tetrazine-mediated bioorthogonal prodrug-prodrug activation.

Authors:  Kevin Neumann; Alessia Gambardella; Annamaria Lilienkampf; Mark Bradley
Journal:  Chem Sci       Date:  2018-07-12       Impact factor: 9.825

Review 7.  Bioorthogonal Ligations and Cleavages in Chemical Biology.

Authors:  Youshan Li; Hua Fu
Journal:  ChemistryOpen       Date:  2020-08-14       Impact factor: 2.911

8.  Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups.

Authors:  Julian Tu; Dennis Svatunek; Saba Parvez; Hannah J Eckvahl; Minghao Xu; Randall T Peterson; K N Houk; Raphael M Franzini
Journal:  Chem Sci       Date:  2019-11-05       Impact factor: 9.825
  8 in total

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