Jinxia Liu1, Guijuan Zong2, Chengliang Zhang3, Chunsun Li2, Xudong Chen2, Yixin Zhang2. 1. Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China. 2. Department of Hepatic Oncology, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China. 3. Grade 14, Clinical Medicine Medical College, Nantong University, Nantong, Jiangsu Province, People's Republic of China.
Abstract
OBJECTIVE: Increasing evidence suggests that psychological factors are involved in tumor progression. This study investigated the influence of anxiety and serum catecholamines (CAs) on the prognosis of hepatocellular carcinoma (HCC). METHOD: We enrolled 110 HCC patients who underwent tumor resection at the Affiliated Hospital of Nantong University, China, in this long-term investigation between 2005 and 2009. We evaluated anxiety using the Hamilton Anxiety Rating Scale (HAMA) and analyzed CA levels using an ELISA kit. We then assessed the association of each of them with overall survival (OS) and time to recurrence (TTR), as well as with other clinical variables. RESULTS: The HAMA scores significantly correlated with metastasis (P = 0.015), hepatitis B surface antigens (HBsAg) (P = 0.045), and the tumor-node-metastasis stage (P = 0.032), whereas the CA levels also significantly associated with tumor differentiation (P < 0.001). Univariate and multivariate analyses revealed that HAMA scores and CA levels were significant predictors of OS and TTR in HCC patients, with high levels of each being strongly correlated with poor prognosis. CONCLUSION: The HAMA scores and the CA levels were elevated in HCC patients and correlated with OS and TTR, suggesting that they are candidate prognostic markers of HCC.
OBJECTIVE: Increasing evidence suggests that psychological factors are involved in tumor progression. This study investigated the influence of anxiety and serum catecholamines (CAs) on the prognosis of hepatocellular carcinoma (HCC). METHOD: We enrolled 110 HCC patients who underwent tumor resection at the Affiliated Hospital of Nantong University, China, in this long-term investigation between 2005 and 2009. We evaluated anxiety using the Hamilton Anxiety Rating Scale (HAMA) and analyzed CA levels using an ELISA kit. We then assessed the association of each of them with overall survival (OS) and time to recurrence (TTR), as well as with other clinical variables. RESULTS: The HAMA scores significantly correlated with metastasis (P = 0.015), hepatitis B surface antigens (HBsAg) (P = 0.045), and the tumor-node-metastasis stage (P = 0.032), whereas the CA levels also significantly associated with tumor differentiation (P < 0.001). Univariate and multivariate analyses revealed that HAMA scores and CA levels were significant predictors of OS and TTR in HCC patients, with high levels of each being strongly correlated with poor prognosis. CONCLUSION: The HAMA scores and the CA levels were elevated in HCC patients and correlated with OS and TTR, suggesting that they are candidate prognostic markers of HCC.
Authors: Daniela B Bastos; Bruna A M Sarafim-Silva; Maria Lúcia M M Sundefeld; Amanda A Ribeiro; Juliana D P Brandão; Éder R Biasoli; Glauco I Miyahara; Dulce E Casarini; Daniel G Bernabé Journal: PLoS One Date: 2018-08-20 Impact factor: 3.240