Literature DB >> 2786054

Brain and spinal cord levels of histamine in Lewis rats with acute experimental autoimmune encephalomyelitis.

E L Orr1, N C Stanley.   

Abstract

Acute experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with guinea pig spinal cord homogenate emulsified with Mycobacterium tuberculosis-enriched complete Freund's adjuvant (CFA). Control rats were inoculated with CFA alone. Control and EAE rats were killed on days 7, 9, 11, and 13 postinoculation, and regional brain and spinal cord levels of histamine were determined. No regional differences in histamine content between control and EAE rats were seen on day 7 or 9 postinoculation. However, depending on the region, EAE rats exhibited significantly higher levels of histamine in their CNS on day 11 or 13 postinoculation or on both. Thus, regionally and temporally specific increases in brain and spinal cord levels of histamine develop concomitant with or just after the appearance (on day 10 postinoculation) of clinical signs of acute EAE, a finding suggesting that histamine may be involved in the development or expression of acute EAE in Lewis rats.

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Year:  1989        PMID： 2786054     DOI： 10.1111/j.1471-4159.1989.tb07301.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  10 in total

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Review 2.  Interactions of mast cells with the nervous system--recent advances.

Authors:  D Johnson; W Krenger
Journal:  Neurochem Res       Date:  1992-09       Impact factor: 3.996

Review 3.  Mast cell specific proteases in rat brain: changes in rats with experimental allergic encephalomyelitis.

Authors:  A Rouleau; V Dimitriadou; M D Trung Tuong; G F Newlands; H R Miller; J C Schwartz; M Garbarg
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis.

Authors:  Changming Lu; Sean A Diehl; Rajkumar Noubade; Jonathan Ledoux; Mark T Nelson; Karen Spach; James F Zachary; Elizabeth P Blankenhorn; Cory Teuscher
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-18       Impact factor: 11.205

5.  Profile of Circulatory Metabolites in a Relapsing-remitting Animal Model of Multiple Sclerosis using Global Metabolomics.

Authors:  Ak Mangalam; Lm Poisson; E Nemutlu; I Datta; A Denic; P Dzeja; M Rodriguez; R Rattan; S Giri
Journal:  J Clin Cell Immunol       Date:  2013-06-30

6.  Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS.

Authors:  Cory Teuscher; Meena Subramanian; Rajkumar Noubade; Jian Feng Gao; Halina Offner; James F Zachary; Elizabeth P Blankenhorn
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-04       Impact factor: 11.205

7.  Elevated CSF histamine levels in multiple sclerosis patients.

Authors:  Ulf Kallweit; Kosuke Aritake; Claudio L Bassetti; Stephan Blumenthal; Osamu Hayaishi; Michael Linnebank; Christian R Baumann; Yoshihiro Urade
Journal:  Fluids Barriers CNS       Date:  2013-05-09

8.  Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis.

Authors:  V H Secor; W E Secor; C A Gutekunst; M A Brown
Journal:  J Exp Med       Date:  2000-03-06       Impact factor: 14.307

9.  Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria.

Authors:  Walid Beghdadi; Adeline Porcherie; Bradley S Schneider; Séverine Morisset; David Dubayle; Roger Peronet; Michel Dy; Jacques Louis; Jean-Michel Arrang; Salaheddine Mécheri
Journal:  PLoS One       Date:  2009-06-23       Impact factor: 3.240

10.  Neurovascular damage in experimental allergic encephalomyelitis: a target for pharmacological control.

Authors:  C Bolton
Journal:  Mediators Inflamm       Date:  1997       Impact factor: 4.711
  10 in total

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