Literature DB >> 2786040

Functional affinity of antibody to the Haemophilus influenzae type b polysaccharide.

W R Griswold1, A H Lucas, J F Bastian, G Garcia.   

Abstract

The functional affinity, or avidity, of antibody to the capsular polysaccharide of Haemophilus influenzae (Hib-PS) was measured in serum samples from 12 adult male subjects before and after immunization with Hib-PS vaccine. Mean avidity increased from 0.74 nM-1 to 1.5 nM-1 after immunization (P less than .05, paired Student's t test). The Bureau of Biologics reference antiserum had an avidity constant of 12 nM-1, which was the highest of all 25 serum samples studied.

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Year:  1989        PMID： 2786040     DOI： 10.1093/infdis/159.6.1083

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  9 in total

1.  Avidity as a determinant of the protective efficacy of human antibodies to pneumococcal capsular polysaccharides.

Authors:  W R Usinger; A H Lucas
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

2.  A major crossreactive idiotype associated with human antibodies to the Haemophilus influenzae b polysaccharide. Expression in relation to age and immunoglobulin G subclass.

Authors:  A H Lucas; D M Granoff
Journal:  J Clin Invest       Date:  1990-04       Impact factor: 14.808

3.  Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates. Description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation. The Collaborative Vaccine Study Group.

Authors:  D M Granoff; P G Shackelford; S J Holmes; A H Lucas
Journal:  J Clin Invest       Date:  1993-03       Impact factor: 14.808

4.  Phase I clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Haemophilus influenzae type b in human adult volunteers.

Authors:  Gilda Toraño; Maria E Toledo; Alberto Baly; Violeta Fernandez-Santana; Francisco Rodriguez; Yunia Alvarez; Teresita Serrano; Alexis Musachio; Ibis Hernandez; Eugenio Hardy; Arlene Rodríguez; Hector Hernandez; Aristides Aguilar; Raydel Sánchez; Manuel Diaz; Verena Muzio; Jorgelina Dfana; Maria C Rodríguez; Lazaro Heynngnezz; Vicente Verez-Bencomo
Journal:  Clin Vaccine Immunol       Date:  2006-09

5.  Avidity, potency, and cross-reactivity of monoclonal antibodies to pneumococcal capsular polysaccharide serotype 6B.

Authors:  Y Sun; Y i Hwang; M H Nahm
Journal:  Infect Immun       Date:  2001-01       Impact factor: 3.441

6.  An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide.

Authors:  A H Lucas; R J Langley; D M Granoff; M H Nahm; M Y Kitamura; M G Scott
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

7.  Age-related disparity in functional activities of human group C serum anticapsular antibodies elicited by meningococcal polysaccharide vaccine.

Authors:  Shannon L Harris; W James King; Wendy Ferris; Dan M Granoff
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

8.  Complement activation by polyclonal immunoglobulin G1 and G2 antibodies against Staphylococcus aureus, Haemophilus influenzae type b, and tetanus toxoid.

Authors:  R G Bredius; P C Driedijk; M F Schouten; R S Weening; T A Out
Journal:  Infect Immun       Date:  1992-11       Impact factor: 3.441

9.  Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide.

Authors:  A H Lucas; J W Larrick; D C Reason
Journal:  Infect Immun       Date:  1994-09       Impact factor: 3.441
  9 in total

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