Literature DB >> 27859662

A Powerful CD8+ T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant.

Zichao Luo1, Qinjie Wu2, Chengbiao Yang3, Huaimin Wang3, Tao He2, Youzhi Wang3, Zhongyan Wang3, Hao Chen4, Xingyi Li4, Changyang Gong2, Zhimou Yang3.   

Abstract

A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub-unit vaccines and help the production of antibodies.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  adjuvants; cancer therapy; hydrogels; peptides; vaccines

Mesh：

Substances：

Year:  2016        PMID： 27859662     DOI： 10.1002/adma.201601776

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  30 in total

1.  Design of self-assembly dipeptide hydrogels and machine learning via their chemical features.

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Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-20       Impact factor: 11.205

Review 2.  Supramolecular biofunctional materials.

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Journal:  Biomaterials       Date:  2017-03-12       Impact factor: 12.479

Review 3.  Advances in immunotherapy delivery from implantable and injectable biomaterials.

Authors:  David G Leach; Simon Young; Jeffrey D Hartgerink
Journal:  Acta Biomater       Date:  2019-02-13       Impact factor: 8.947

Review 4.  Rational design of hydrogels for immunomodulation.

Authors:  Wenhuan Bu; Yuanhao Wu; Amir M Ghaemmaghami; Hongchen Sun; Alvaro Mata
Journal:  Regen Biomater       Date:  2022-02-22

Review 5.  Enzymatic Noncovalent Synthesis.

Authors:  Hongjian He; Weiyi Tan; Jiaqi Guo; Meihui Yi; Adrianna N Shy; Bing Xu
Journal:  Chem Rev       Date:  2020-08-19       Impact factor: 60.622

6.  Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors.

Authors:  Kuan Hu; Wenyu Wu; Lin Xie; Hao Geng; Yiding Zhang; Masayuki Hanyu; Lulu Zhang; Yinghuan Liu; Kotaro Nagatsu; Hisashi Suzuki; Jialin Guo; Yundong Wu; Zigang Li; Feng Wang; Mingrong Zhang
Journal:  Acta Pharm Sin B       Date:  2021-09-22       Impact factor: 14.903

7.  A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Authors:  Tingting Wang; Dangge Wang; Haijun Yu; Bing Feng; Fangyuan Zhou; Hanwu Zhang; Lei Zhou; Shi Jiao; Yaping Li
Journal:  Nat Commun       Date:  2018-04-18       Impact factor: 14.919

8.  Delivery of MSCs with a Hybrid β-Sheet Peptide Hydrogel Consisting IGF-1C Domain and D-Form Peptide for Acute Kidney Injury Therapy.

Authors:  Hongfeng Wang; Yuna Shang; Xiaoniao Chen; Zhongyan Wang; Dashuai Zhu; Yue Liu; Chuyue Zhang; Pu Chen; Jie Wu; Lingling Wu; Deling Kong; Zhimou Yang; Zongjin Li; Xiangmei Chen
Journal:  Int J Nanomedicine       Date:  2020-06-17

9.  Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination.

Authors:  Xiaobo Xi; Tong Ye; Shuang Wang; Xiangming Na; Jianghua Wang; Shuang Qing; Xiaoyong Gao; Changlong Wang; Feng Li; Wei Wei; Guanghui Ma
Journal:  Sci Adv       Date:  2020-05-22       Impact factor: 14.136

10.  Co-assembled Supramolecular Nanofibers With Tunable Surface Properties for Efficient Vaccine Delivery.

Authors:  Zhongyan Wang; Chunhua Ren; Yuna Shang; Cuihong Yang; Qingxiang Guo; Liping Chu; Jianfeng Liu
Journal:  Front Chem       Date:  2020-07-21       Impact factor: 5.221
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