BACKGROUND: Impaired psychological function is common among lung transplant candidates and may affect clinical outcomes following transplantation. Although numerous studies have examined the relationship between pretransplant depression, quality of life (QoL), and post-transplant outcomes, few have examined the relationship between depression and QoL shortly following transplantation and subsequent clinical outcomes. We therefore examined the association between depression, QoL, and short-term mortality in a consecutive series of lung transplant recipients. METHODS: Depression (Patient Health Questionnaire-9; Hospital Anxiety and Depression Scale; Centers for Epidemiologic Studies Depression Scale) and QoL (UCSD Shortness of Breath Questionnaire; Pulmonary Quality of Life Scale) were assessed prior to transplantation (median 0.9 months [IQR=1.6]) and again approximately 2 weeks following transplantation (median=0.5 months [IQR=0.5]), in a series of 66 patients transplanted between March 2013 and April 2014. The association between psychiatric diagnoses from participants' comprehensive pretransplant assessment and mortality also was examined. Cox proportional hazards models were used to examine the association between depression, QoL, and mortality. RESULTS: During a median follow-up of 2.8 years (range 0.4-3.3), 21 patients died (32%). Greater depressive symptoms assessed shortly after transplant were associated with subsequent mortality (HR=2.17 [1.01, 4.67], P=.048), and this relationship persisted after controlling for primary graft dysfunction, duration of transplant hospitalization, and gender. In contrast, neither pretransplant depression, history of depression, nor QoL was associated with mortality. CONCLUSIONS: Greater post-transplant depressive symptoms are independently associated with mortality among lung transplant recipients.
BACKGROUND: Impaired psychological function is common among lung transplant candidates and may affect clinical outcomes following transplantation. Although numerous studies have examined the relationship between pretransplant depression, quality of life (QoL), and post-transplant outcomes, few have examined the relationship between depression and QoL shortly following transplantation and subsequent clinical outcomes. We therefore examined the association between depression, QoL, and short-term mortality in a consecutive series of lung transplant recipients. METHODS:Depression (Patient Health Questionnaire-9; Hospital Anxiety and Depression Scale; Centers for Epidemiologic Studies Depression Scale) and QoL (UCSD Shortness of Breath Questionnaire; Pulmonary Quality of Life Scale) were assessed prior to transplantation (median 0.9 months [IQR=1.6]) and again approximately 2 weeks following transplantation (median=0.5 months [IQR=0.5]), in a series of 66 patients transplanted between March 2013 and April 2014. The association between psychiatric diagnoses from participants' comprehensive pretransplant assessment and mortality also was examined. Cox proportional hazards models were used to examine the association between depression, QoL, and mortality. RESULTS: During a median follow-up of 2.8 years (range 0.4-3.3), 21 patients died (32%). Greater depressive symptoms assessed shortly after transplant were associated with subsequent mortality (HR=2.17 [1.01, 4.67], P=.048), and this relationship persisted after controlling for primary graft dysfunction, duration of transplant hospitalization, and gender. In contrast, neither pretransplant depression, history of depression, nor QoL was associated with mortality. CONCLUSIONS: Greater post-transplant depressive symptoms are independently associated with mortality among lung transplant recipients.
Authors: Sarah E Van Pilsum Rasmussen; Alexander Ferzola; Carisa M Cooney; Jaime T Shores; Wp Andrew Lee; Emily Goldman; Christina L Kaufman; Gerald Brandacher; Dorry L Segev; Macey L Henderson Journal: SAGE Open Med Date: 2020-07-09
Authors: Nicholas A Kolaitis; Allison Soong; Pavan Shrestha; Hanjing Zhuo; John Neuhaus; Patti P Katz; John R Greenland; Jeffrey Golden; Lorriana E Leard; Rupal J Shah; Steven R Hays; Jasleen Kukreja; Mary Ellen Kleinhenz; Paul D Blanc; Jonathan P Singer Journal: J Thorac Cardiovasc Surg Date: 2018-02-22 Impact factor: 5.209
Authors: Patrick J Smith; Jordan M Dunitz; Amy Lucy; Sarah E Hempstead; Erin Tallarico; Albert Faro; Joseph M Pilewski; Kathleen J Ramos Journal: Clin Transplant Date: 2020-08-17 Impact factor: 2.863
Authors: Joanna M Schaenman; Joshua M Diamond; John R Greenland; Cynthia Gries; Cassie C Kennedy; Amit D Parulekar; Dmitry Rozenberg; Jonathan P Singer; Lianne G Singer; Laurie D Snyder; Sangeeta Bhorade Journal: Am J Transplant Date: 2020-12-24 Impact factor: 9.369
Authors: James A Blumenthal; Patrick J Smith; Andrew Sherwood; Stephanie Mabe; Laurie Snyder; Courtney Frankel; Daphne C McKee; Natalie Hamilton; Francis J Keefe; Sheila Shearer; Jeanne Schwartz; Scott Palmer Journal: Transplant Direct Date: 2020-02-18
Authors: Marion J Wessels-Bakker; Eduard A van de Graaf; Johanna M Kwakkel-van Erp; Harry G Heijerman; Wiepke Cahn; Renske Schappin Journal: J Clin Nurs Date: 2021-07-02 Impact factor: 4.423