K Ihara1,2, C Fukano1, T Ayabe3, M Fukami3, T Ogata3,4, T Kawamura5, T Urakami6, N Kikuchi7, I Yokota8,9, K Takemoto10,11, T Mukai12,13, A Nishii14, T Kikuchi15,16, T Mori17,18, N Shimura19, G Sasaki20, R Kizu21, N Takubo22,23, S Soneda24, T Fujisawa25, R Takaya26, Z Kizaki27, S Kanzaki28, K Hanaki29, N Matsuura30,31, Y Kasahara32, K Kosaka33, T Takahashi34, K Minamitani35, S Matsuo36, H Mochizuki37, K Kobayashi38, A Koike39, R Horikawa40, S Teno41, K Tsubouchi42, T Mochizuki43,44, Y Igarashi45, S Amemiya15, S Sugihara46. 1. Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2. Department of Paediatrics, Oita University School of Medicine, Yufu, Japan. 3. Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan. 4. Department of Paediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan. 5. Department of Paediatrics, Osaka City University Hospital, Osaka, Japan. 6. Department of Paediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan. 7. Department of Paediatrics, Yokohama City Minato Red Cross Hospital, Yokohama, Japan. 8. Department of Clinical Laboratory, Shikoku Medical Center for Children and Adults, Zentsuji, Japan. 9. Department of Paediatrics, Graduate School of Medical Sciences Tokushima University, Tokushima, Japan. 10. Department of Paediatrics, Ehime University Hospital, Toon, Japan. 11. Department of Paediatrics, Sumitomo Besshi Hospital, Niihama, Japan. 12. Department of Paediatrics, Asahikawa Medical University Hospital, Asahikawa, Japan. 13. Department of Paediatrics, Asahikawa-Kosei General Hospital, Asahikawa, Japan. 14. Department of Paediatrics, JR Sendai Hospital, Sendai, Japan. 15. Department of Paediatrics, Saitama Medical University Hospital, Saitama, Japan. 16. Department of Paediatrics, Niigata University Medical and Dental Hospital, Niigata, Japan. 17. Department of Paediatrics, Nagano Red Cross Hospital, Nagano, Japan. 18. Department of Paediatrics, Shinshu Ueda Medical Centre, Ueda, Japan. 19. Department of Paediatrics, Dokkyo Medical University Hospital, Shimotsuga, Japan. 20. Department of Paediatrics, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan. 21. Department of Paediatrics, Yokosuka Kyosai Hospital, Yokosuka, Japan. 22. Department of Pediatrics, Kitasato University Hospital, Sagamihara, Japan. 23. Department of Paediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan. 24. Department of Paediatrics, St Marianna University School of Medicine, Kawasaki, Japan. 25. Department of Paediatrics, National Mie Hospital, Tsu, Japan. 26. Department of Paediatrics, Osaka Medical College, Takatsuki, Japan. 27. Department of Paediatrics, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan. 28. Department of Paediatrics, Tottori University Faculty of Medicine, Yonago, Japan. 29. Department of Paediatrics, Tottori Prefectural Kousei Hospital, Kurayoshi, Japan. 30. Department of Paediatrics, Teine Keijinkai Hospital, Sapporo, Japan. 31. Department of Early Childhood Care and Education, Seitoku University Junior College, Matsudo, Japan. 32. Department of Paediatrics, Kanazawa University, Kanazawa, Japan. 33. Department of Paediatrics, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan. 34. Takahashi Clinic, Kobe, Japan. 35. Department of Paediatrics, Teikyo University Chiba Medical Center, Ichihara, Japan. 36. Matsuo Kodomo Clinic, Kyoto, Japan. 37. Department of Metabolism and Endocrinology, Saitama Children's Medical Centre, Saitama, Japan. 38. Department of Paediatrics, University of Yamanashi Hospital, Chuo, Japan. 39. Miyanosawa Koike Child Clinic, Sapporo, Japan. 40. Division of Endocrinology and Metabolism, Department of Medical Subspecialties, National Medical Centre for Children and Mothers, Tokyo, Japan. 41. Teno Clinic, Izumo, Japan. 42. Department of Paediatrics, Chuno Kosei Hospital, Seki, Japan. 43. Department of Paediatrics, Osaka City General Hospital, Osaka, Japan. 44. Department of Paediatrics, Osaka Police Hospital, Osaka, Japan. 45. Igarashi Children's Clinic, Sendai, Japan. 46. Department of Paediatrics, Tokyo Women's Medical University Medical Centre East, Tokyo, Japan.
Abstract
AIM: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. METHODS: We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. RESULTS: The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075]. CONCLUSIONS: The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.
AIM: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. METHODS: We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. RESULTS: The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075]. CONCLUSIONS: The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.
Authors: S Surendran; A Adaikalakoteswari; P Saravanan; I A Shatwaan; J A Lovegrove; K S Vimaleswaran Journal: Genes Nutr Date: 2018-02-06 Impact factor: 5.523