Literature DB >> 27859351

Exosomes in immunoregulation of chronic lung diseases.

K P Hough1, D Chanda1, S R Duncan1, V J Thannickal1, J S Deshane1.   

Abstract

Exosomes are nano-sized, membrane-bound vesicles released from cells that transport cargo including DNA, RNA, and proteins, between cells as a form of intercellular communication. In addition to their role in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregulation that can modulate antigen presentation, immune activation, suppression, and surveillance. This article summarizes how these multifaceted functions of exosomes may promote development and/or progression of chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. The potential of exosomes as a novel therapeutic is also discussed.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  chronic lung diseases; exosomes; extracellular vesicles; immunoregulation; inflammation

Mesh：

Substances：

Year:  2016        PMID： 27859351      PMCID： PMC5462600          DOI： 10.1111/all.13086

Source DB:  PubMed          Journal:  Allergy        ISSN： 0105-4538            Impact factor:   13.146


  143 in total

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7.  MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells.

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6.  Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells.

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7.  Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.

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10.  Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization.

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