| Literature DB >> 27859213 |
Mehran Pashirzad1, Mojtaba Shafiee2, Farzad Rahmani1, Reihane Behnam-Rassouli3, Fatemeh Hoseinkhani4, Mikhail Ryzhikov5, Maryam Moradi Binabaj1, Mohammad Reza Parizadeh1, Amir Avan6,7, Seyed Mahdi Hassanian1,5,8,9.
Abstract
Wnt5a initiates pro-inflammatory responses through activation of non-canonical Wnt signaling pathway. Pro-inflammatory functions of Wnt5a trigger pro-inflammatory signaling cascades and increase secretion of pro-inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding, and clinical management of these diseases. J. Cell. Physiol. 232: 1611-1616, 2017.Entities:
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Year: 2017 PMID： 27859213 DOI： 10.1002/jcp.25687
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384