BACKGROUND: The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. METHODS: In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression. RESULTS: The prevalence of undervaccination was 60.6% (median 16 days) and decreasing (p < 0.0001). Among 145 cases and 2,900 controls, 58 (40.0%) and 721 (24.9%) were undervaccinated (OR 2.28, 95% CI 1.57-3.31). The attributable risk percent was 22.5% (95% CI 14.5-27.9). CONCLUSIONS: Undervaccination was decreasing. Approximately up to one-fifth pertussis cases in children aged 3-35 months could have been prevented with on-time vaccination.
BACKGROUND: The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. METHODS: In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression. RESULTS: The prevalence of undervaccination was 60.6% (median 16 days) and decreasing (p < 0.0001). Among 145 cases and 2,900 controls, 58 (40.0%) and 721 (24.9%) were undervaccinated (OR 2.28, 95% CI 1.57-3.31). The attributable risk percent was 22.5% (95% CI 14.5-27.9). CONCLUSIONS: Undervaccination was decreasing. Approximately up to one-fifth pertussis cases in children aged 3-35 months could have been prevented with on-time vaccination.
Authors: Jason M Glanz; Komal J Narwaney; Sophia R Newcomer; Matthew F Daley; Simon J Hambidge; Ali Rowhani-Rahbar; Grace M Lee; Jennifer C Nelson; Allison L Naleway; James D Nordin; Marlene M Lugg; Eric S Weintraub Journal: JAMA Pediatr Date: 2013-11 Impact factor: 16.193
Authors: Amanda F Dempsey; Sarah Schaffer; Dianne Singer; Amy Butchart; Matthew Davis; Gary L Freed Journal: Pediatrics Date: 2011-10-03 Impact factor: 7.124
Authors: Elizabeth T Luman; Lawrence E Barker; Kate M Shaw; Mary Mason McCauley; James W Buehler; Larry K Pickering Journal: JAMA Date: 2005-03-09 Impact factor: 56.272
Authors: Jason M Glanz; Sophia R Newcomer; Komal J Narwaney; Simon J Hambidge; Matthew F Daley; Nicole M Wagner; David L McClure; Stan Xu; Ali Rowhani-Rahbar; Grace M Lee; Jennifer C Nelson; James G Donahue; Allison L Naleway; James D Nordin; Marlene M Lugg; Eric S Weintraub Journal: JAMA Pediatr Date: 2013-03-01 Impact factor: 16.193