OBJECTIVE: To assess the usefulness of arterial spin labelling (ASL) compared with dynamic susceptibility contrast (DSC) perfusion MRI for typical paediatric neuroimaging applications at 1.5 T. METHODS: 52 children (age: 4 months-17 years) with a variety of neurological disorders were scanned using three-dimensional ASL and echoplanar imaging DSC sequences. All images were reviewed by an experienced neuroradiologist; image quality was recorded as "good", "acceptable" or "poor" and diagnostic value was noted as being "greater", "similar" or "less" for ASL when compared with DSC. RESULTS: ASL cerebral blood flow (CBF) images were judged to be acceptable in 89% of cases, poor in 11% of cases and good in 0% of cases, while DSC CBF images were acceptable in 88% of cases, poor in 12% of cases and good in 0% of cases. ASL images were judged to have better diagnostic value than DSC images in 28% of cases, about the same in 58% of cases and worse in 14% of cases. CONCLUSION: The results of this study suggest that ASL offers a realistic alternative to DSC in the paediatric setting for the majority of cases encountered in this study. However, there are some situations where DSC outperforms ASL; so, care is required to choose the most appropriate technique for the pathology under investigation. A larger study is required to corroborate these preliminary findings. Advances in knowledge: ASL is a relatively new perfusion imaging technique whose use has not been explored extensively in the paediatric setting. This work is a preliminary study to evaluate its usefulness in paediatric neuroimaging.
OBJECTIVE: To assess the usefulness of arterial spin labelling (ASL) compared with dynamic susceptibility contrast (DSC) perfusion MRI for typical paediatric neuroimaging applications at 1.5 T. METHODS: 52 children (age: 4 months-17 years) with a variety of neurological disorders were scanned using three-dimensional ASL and echoplanar imaging DSC sequences. All images were reviewed by an experienced neuroradiologist; image quality was recorded as "good", "acceptable" or "poor" and diagnostic value was noted as being "greater", "similar" or "less" for ASL when compared with DSC. RESULTS:ASL cerebral blood flow (CBF) images were judged to be acceptable in 89% of cases, poor in 11% of cases and good in 0% of cases, while DSC CBF images were acceptable in 88% of cases, poor in 12% of cases and good in 0% of cases. ASL images were judged to have better diagnostic value than DSC images in 28% of cases, about the same in 58% of cases and worse in 14% of cases. CONCLUSION: The results of this study suggest that ASL offers a realistic alternative to DSC in the paediatric setting for the majority of cases encountered in this study. However, there are some situations where DSC outperforms ASL; so, care is required to choose the most appropriate technique for the pathology under investigation. A larger study is required to corroborate these preliminary findings. Advances in knowledge: ASL is a relatively new perfusion imaging technique whose use has not been explored extensively in the paediatric setting. This work is a preliminary study to evaluate its usefulness in paediatric neuroimaging.
Authors: Thomas Blauwblomme; Olivier Naggara; Francis Brunelle; David Grévent; Stéphanie Puget; Federico Di Rocco; Kevin Beccaria; Giovanna Paternoster; Marie Bourgeois; Manoelle Kossorotoff; Michel Zerah; Christian Sainte-Rose; Nathalie Boddaert Journal: J Neurosurg Pediatr Date: 2015-01-30 Impact factor: 2.375
Authors: Thomas Blauwblomme; Nathalie Boddaert; Nicole Chémaly; Catherine Chiron; Mélanie Pages; Pascale Varlet; Marie Bourgeois; Nadia Bahi-Buisson; Anna Kaminska; David Grevent; Francis Brunelle; Christian Sainte-Rose; Frédérique Archambaud; Rima Nabbout Journal: Epilepsy Res Date: 2014-10-13 Impact factor: 3.045
Authors: R L Wolf; D C Alsop; I Levy-Reis; P T Meyer; J A Maldjian; J Gonzalez-Atavales; J A French; A Alavi; J A Detre Journal: AJNR Am J Neuroradiol Date: 2001-08 Impact factor: 3.825
Authors: K W Yeom; L A Mitchell; R M Lober; P D Barnes; H Vogel; P G Fisher; M S Edwards Journal: AJNR Am J Neuroradiol Date: 2013-08-01 Impact factor: 3.825
Authors: Vera C Keil; Nolan S Hartkamp; Daniel J A Connolly; Giovanni Morana; Marjolein H G Dremmen; Henk J M M Mutsaerts; Maarten H Lequin Journal: Pediatr Radiol Date: 2018-11-17
Authors: Aaron Y Mochizuki; Isaura M Frost; Melina B Mastrodimos; Ashley S Plant; Anthony C Wang; Theodore B Moore; Robert M Prins; Paul S Weiss; Steven J Jonas Journal: ACS Chem Neurosci Date: 2017-12-27 Impact factor: 4.418