V Korkmaz1, Z Kurdoglu2, M Alisik3, E Turgut2, O O Sezgın4, H Korkmaz5, Y Ergun2, O Erel3. 1. Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey. korkmazvakkas@gmail.com. 2. Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey. 3. Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey. 4. Department of Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey. 5. Department of Physiology, Hacettepe University, Ankara, Turkey.
Abstract
AIM: To evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis. MATERIALS AND METHODS: A total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups. RESULTS: The disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05). CONCLUSION: Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.
RCT Entities:
AIM: To evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis. MATERIALS AND METHODS: A total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups. RESULTS: The disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05). CONCLUSION:Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.
Authors: Yvonne S Nkabyo; Thomas R Ziegler; Li H Gu; Walter H Watson; Dean P Jones Journal: Am J Physiol Gastrointest Liver Physiol Date: 2002-12 Impact factor: 4.052