Literature DB >> 2785834

Modulation of phospholipase A2 activity in human fibroblasts.

E Solito1, L Parente.   

Abstract

1. Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2). 2. rIL-1 beta, bradykinin (Bk) and arachidonic acid (AA) significantly stimulated PGE2 release from HSF incubated overnight in the presence of either interleukin. 3. Hydrocortisone inhibited the PGE2 release induced by rIL-1 beta and Bk, but not by AA. 4. The steroid inhibitory effect was reversed by actinomycin D as well as by an anti-lipocortin monoclonal antibody. 5. The results suggest that in HSF, rIL-1 beta is able to stimulate both cyclo-oxygenase and phospholipase A2 (PLA2) activity. 6. The stimulation of PLA2 activity by rIL-1 beta is inhibited by hydrocortisone, probably via induction of lipocortin-like proteins.

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Year:  1989        PMID： 2785834      PMCID： PMC1854403          DOI： 10.1111/j.1476-5381.1989.tb11865.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  19 in total

1.  Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.

Authors:  B P Wallner; R J Mattaliano; C Hession; R L Cate; R Tizard; L K Sinclair; C Foeller; E P Chow; J L Browing; K L Ramachandran
Journal:  Nature       Date:  1986 Mar 6-12       Impact factor: 49.962

2.  The importance of phospholipase-A2 in prostaglandin biosynthesis.

Authors:  R J Flower; G J Blackwell
Journal:  Biochem Pharmacol       Date:  1976-02-01       Impact factor: 5.858

3.  Purification of a factor from human blood monocyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissues.

Authors:  J M Dayer; M L Stephenson; E Schmidt; W Karge; S M Krane
Journal:  FEBS Lett       Date:  1981-02-23       Impact factor: 4.124

4.  Anti-phospholipase proteins.

Authors:  M Di Rosa; R J Flower; F Hirata; L Parente; F Russo-Marie
Journal:  Prostaglandins       Date:  1984-10

5.  Relationship between the anti-phospholipase and anti-inflammatory effects of glucocorticoid-induced proteins.

Authors:  L Parente; M Di Rosea; R J Flower; P Ghiara; R Meli; P Persico; J A Salmon; J N Wood
Journal:  Eur J Pharmacol       Date:  1984-03-23       Impact factor: 4.432

6.  Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones.

Authors:  H Besedovsky; A del Rey; E Sorkin; C A Dinarello
Journal:  Science       Date:  1986-08-08       Impact factor: 47.728

7.  Induction of cyclo-oxygenase by interleukin-1 in rheumatoid synovial cells.

Authors:  L A O'Neill; M L Barrett; G P Lewis
Journal:  FEBS Lett       Date:  1987-02-09       Impact factor: 4.124

8.  Mechanism of enhanced fibroblast arachidonic acid metabolism by mononuclear cell factor.

Authors:  P J Whiteley; P Needleman
Journal:  J Clin Invest       Date:  1984-12       Impact factor: 14.808

9.  The presence of lipocortin in human embryonic skin fibroblasts and its regulation by anti-inflammatory steroids.

Authors:  M Errasfa; B Rothhut; A Fradin; C Billardon; J L Junien; J Bure; F Russo-Marie
Journal:  Biochim Biophys Acta       Date:  1985-11-20

10.  Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action.

Authors:  J Chang; S C Gilman; A J Lewis
Journal:  J Immunol       Date:  1986-02-15       Impact factor: 5.422
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  14 in total

1.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

2.  Phospholipase A2 is secreted by murine keratinocytes after stimulation with IL-1 alpha and TNF-alpha.

Authors:  B C Bastian; R J Schacht; E Kämpgen; E B Bröcker
Journal:  Arch Dermatol Res       Date:  1996-03       Impact factor: 3.017

3.  Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes.

Authors:  M Serres; J Viac; C Comera; D Schmitt
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

4.  Interleukin-1 potentiates histamine-induced release of prostacyclin from human endothelial cells.

Authors:  H A Bull; P M Dowd
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

5.  The effect of adrenalectomy on interleukin-1 release in vitro and in vivo.

Authors:  M Perretti; C Becherucci; G Scapigliati; L Parente
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

Review 6.  Therapy with topical corticosteroids.

Authors:  W Sterry
Journal:  Arch Dermatol Res       Date:  1992       Impact factor: 3.017

7.  Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis.

Authors:  Lucila Busch; Valeria Miozza; Leonor Sterin-Borda; Enri Borda
Journal:  Inflamm Res       Date:  2009-04-04       Impact factor: 4.575

8.  Expression of human recombinant lipocortin I in a wheat-germ cell-free system and Xenopus oocytes. Lipocortin is not secreted.

Authors:  B M Frey; F J Frey; V R Lingappa; H Trachsel
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

9.  Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice.

Authors:  M Perretti; E Solito; L Parente
Journal:  Agents Actions       Date:  1992-01

10.  Increase of extracellular brain calcium involved in interleukin-1 beta-induced pyresis in the rabbit: antagonism by dexamethasone.

Authors:  M Palmi; M Frosini; C Becherucci; G P Sgaragli; L Parente
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739
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