Literature DB >> 2785798

Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus.

T Tanaka1, O Saiki, S Negoro, T Igarashi, T Kuritani, H Hara, M Suemura, S Kishimoto.   

Abstract

Using radiolabeled interleukin-2 (IL-2), affinity cross-linking and binding assays revealed that the expression of intermediate-affinity IL-2 binding molecules (p70/75) on freshly prepared T cells from patients with systemic lupus erythematosus (SLE) was significantly decreased in comparison with that in normal subjects. The proliferative response of T cells to high doses of IL-2 was also reduced in patients with SLE. The decreased expression of p70/75 reflects the hyporesponsiveness to IL-2 of T cells in patients with SLE.

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Year:  1989        PMID： 2785798     DOI： 10.1002/anr.1780320507

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  6 in total

1.  Relations between surface expression of the interleukin-2 receptor and release of the soluble form of the receptor in cultured mononuclear cells from patients with rheumatoid arthritis or systemic lupus erythematosus.

Authors:  M Itoh; Y Goto; Y Ohta; Y Goto; H Ohashi
Journal:  Clin Rheumatol       Date:  1998       Impact factor: 2.980

2.  Expression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: a prospective study.

Authors:  E Y Chan; C S Lau; H Zola
Journal:  J Clin Pathol       Date:  1996-08       Impact factor: 3.411

Review 3.  The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic implications.

Authors:  D A Horwitz; C O Jacob
Journal:  Springer Semin Immunopathol       Date:  1994

Review 4.  The role of cytokines in the immunopathogenesis of lupus.

Authors:  B S Handwerger; V Rus; L da Silva; C S Via
Journal:  Springer Semin Immunopathol       Date:  1994

5.  Autoantigen-specific T cell proliferation induced by the ribosomal P2 protein in patients with systemic lupus erythematosus.

Authors:  M K Crow; G DelGiudice-Asch; J B Zehetbauer; J L Lawson; N Brot; H Weissbach; K B Elkon
Journal:  J Clin Invest       Date:  1994-07       Impact factor: 14.808

Review 6.  Infection and Lupus: Which Causes Which?

Authors:  Sarah Doaty; Harsh Agrawal; Erin Bauer; Daniel E Furst
Journal:  Curr Rheumatol Rep       Date:  2016-03       Impact factor: 4.686
  6 in total

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